grant
Project-002
Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 17 Jul 2012Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AddressAllograft ToleranceAllograftingAnti-Rejection TherapyAntigen-Presenting CellsAntigensBiological MarkersCD152CD152 AntigenCD152 GeneCD154CD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD40LCD40LGCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCTLA 4CTLA-4 GeneCTLA4CTLA4 geneCTLA4-TMCardiac TransplantationCell BodyCellsChronicClinicClinicalCytotoxic T-Lymphocyte Protein 4Cytotoxic T-Lymphocyte-Associated Antigen 4Cytotoxic T-Lymphocyte-Associated Protein 4Cytotoxic T-Lymphocyte-Associated Serine Esterase-4ExhibitsExposure toFetusFrequenciesGestationHSC transplantationHeartHeart GraftingHeart TransplantationHematopoietic Stem Cell TransplantHematopoietic Stem Cell TransplantationImmuneImmunesImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunosuppressive TherapyInfectionKnowledgeLYT3LinkMaintenanceMediatingMemoryModelingPD 1PD-1PD1Pathway interactionsPhenotypePhysiologicPhysiologicalPostpartum PeriodPredispositionPregnancyProcessRegulatory T-LymphocyteReportingResistanceResistance developmentResistant developmentSkin graftSusceptibilityT memory cellT-CellsT-LymphocyteT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTNFSF5TNFSF5 geneTRAP GeneTestingTherapeuticTherapeutic immunosuppressionTransplant RecipientsTransplantationTransplantation ToleranceTregTreg adoptive therapyTreg therapyWeaningaccessory celladoptive therapy of regulatory T cellsafter pregnancyallogenic skin graftanergyartificial immunosuppressionbio-markersbiologic markerbiomarkerblood stem cell transplantationcardiac allograftcardiac graftchromatin remodelingcytotoxic T-lymphocyte antigen 4developing resistanceexhaustexhaustionexpectationexperienceglobal gene expressionglobal transcription profileheart allograftheart transplanthematopoietic cell transplantationhematopoietic cellular transplantationhematopoietic progenitor cell transplantationimmune suppressionimmune suppressive activityimmune suppressive functionimmunogenimmunosuppression therapyimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseinsightmemory CD4 T cellmemory CD4 T lymphocytememory T lymphocytenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoffspringpathwaypharmacologicpost pregnancypost-partumpreventpreventingprogrammed cell death 1programmed cell death protein 1programmed death 1programsregulatory T-cellsresistantsexsle2synergismsystemic lupus erythematosus susceptibility 2thymus derived lymphocytetranscriptometransplanttransplant patient
Description preview
Project 2 Summary
Transplantation tolerance promises to facilitate long-term allograft acceptance while avoiding the need for
life-long immunosuppression and its associated problems. In the past decade, operational clinical transplantation
tolerance has been achievable through hematopoietic stem cell transplantation or weaning of conventional…
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