grant
Project-001
NIHUS FederalResearch GrantFY20250-11 years old12-20 years old21+ years oldAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAdolescenceAdultAdult HumanAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntigen PresentationBindingBlood PlasmaBone-Derived Transforming Growth FactorCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCSIFCSIF GeneCSIF-10Cell BodyCell Communication and SignalingCell Growth in NumberCell MultiplicationCell ProliferationCell SignalingCellsCellular Immune FunctionCellular ProliferationChildChild YouthChildhoodChildren (0-21)Clinical Treatment MoabComplexCytokine Synthesis Inhibitory FactorCytokine Synthesis Inhibitory Factor GeneDataEmigrantEnvironmentEventHIVHIV InfectionsHTLV-III InfectionsHTLV-III-LAV InfectionsHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsIL-10IL-10 GeneIL10IL10 geneIL10AIL10A GeneImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune responseImmune systemImmunesImmunityImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunologyImmunomodulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImpairmentInfantInfectionInflammatoryInterleukin 10 PrecursorInterleukin 10 Precursor GeneInterleukin-10Interleukin-10 GeneInterruptionIntracellular Communication and SignalingInvestigatorsKnowledgeLAV-HTLV-IIILeadLifeLymph Node Reticuloendothelial SystemLymph node properLymphadenopathy-Associated VirusLymphatic nodesM mulattaM. mulattaMacacaMacaca mulattaMacaca rhesusMacaqueMaintenanceMediatingMilk Growth FactorMissionModelingMolecular InteractionMonoclonal AntibodiesMorbidityMorbidity - disease rateNatureNeonatalOutputPathway interactionsPb elementPlasmaPlasma SerumPlatelet Transforming Growth FactorRegulatory T-LymphocyteResearchResearch PersonnelResearchersReticuloendothelial System, Serum, PlasmaRhesus MacaqueRhesus MonkeyRoleSHIVSIVSamplingSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSimian Immunodeficiency VirusesStem Cell likeStimulusSystemT cell responseT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTGF BTGF Beta Signaling PathwayTGF-betaTGF-βTGF-β Signaling PathwayTGFbetaTGFβTGIF GeneTeff cellTestingThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTimeTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTregViralViral reservoirViremiaVirusVirus reservoirVirus-HIVadolescence (12-20)adulthoodanti-viral immunityantiretroviral therapyantiretroviral treatmentantiviral immunitybiobankbiological signal transductionbiorepositoryclinical trial protocolcytokinedetermine efficacyeffector T cellefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacygene signaturesgenetic signatureheavy metal Pbheavy metal leadhost responseimmune functionimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedin vivoinfant infectioninfected infantinterdisciplinary approachkidslymph glandlymph nodeslymphnodesmAbsmemory CD4 T cellmemory CD4 T lymphocytemicrobialmonoclonal Absmortalitymultidisciplinary approachmultiomicsmultiple omicsneonatal immune systemneonatal periodnovelpanomicspathogenpathwaypediatricpediatric HIVpediatric human immunodeficiency virusperinatal HIVperinatal periodperinatal phasepressureprogenitor capacityprogenitor cell likeprogenitor-likeprogramsregulatory T-cellssimian HIVsimian human immunodeficiency virussocial rolestem cell characteristicsstem-likestemnesssynergismviraemiaviral reboundviral sepsisvirus reboundvirusemiayoungster
Description preview
ABSTRACT – Project 1
The overall objective of this Program project application is to generate a comprehensive understanding of the
complex host-pathogen interactions critical for HIV reservoir seeding and persistence such that novel cure
strategies truly targeted for the unique immune environment of children living with HIV (CLWH) can be created.…
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