grant
Progressive Multifocal Leukoenephalopathy: Endemic Viruses and Lethal Brain Disease
Organization BROWN UNIVERSITYLocation PROVIDENCE, UNITED STATESPosted 1 May 2020Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AIDS patientsAnatomic SitesAnatomic structuresAnatomyAtrophic ArthritisAutoimmune DiseasesBiologyBone MarrowBone Marrow Reticuloendothelial SystemBrainBrain DiseasesBrain DisordersBrain Nervous SystemCNS DiseasesCNS Nervous SystemCNS disorderCell BodyCellsCentral Nervous SystemCentral Nervous System DiseasesCentral Nervous System DisordersChoroid PlexusChronic small plaque psoriasisClinicComplicationCrohn diseaseCrohn'sCrohn's diseaseCrohn's disorderDevelopmentDiscoid psoriasisDiseaseDisorderDisseminated SclerosisDysfunctionEncephalonEncephalon DiseasesFunctional disorderGranulomatous EnteritisHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopoietic CancerHumanImmune SurveillanceImmune mediated therapyImmune systemImmunologic SurveillanceImmunologically Directed TherapyImmunosurveillanceImmunotherapyIndividualInfectionIntracranial CNS DisordersIntracranial Central Nervous System DisordersInvadedJC PolyomavirusJC Polyomavirus EncephalitisJC Polyomavirus EncephalopathyJC VirusKidneyKidney Urinary SystemLifeLupus Erythematosus DisseminatusLytic CycleLytic InfectionLytic PhaseMalignant Hematologic NeoplasmMediatingMeningealMicroRNAsModern ManMultiple SclerosisNeuraxisNummular psoriasisPatientsPhysiopathologyPlaque psoriasisPlayPolyomaPolyoma VirusesPolyomavirusPolyomavirus JCVPopulationProgressive Multifocal LeukoencephalopathyPsoriasis vulgarisReceptor ProteinRegulationRheumatoid ArthritisRoleSLESightStructure of choroid plexusSystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusTranslatingViralVirusVisionWorkacquired immunodeficiency syndrome patientautoimmune conditionautoimmune disorderautoimmunity diseasebiomarker identificationbrain parenchymadevelopmentaldisseminated lupus erythematosuseleocolitisextracellular vesiclesidentification of biomarkersidentification of new biomarkersimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyinsular sclerosismacrogliamarker identificationmiRNAnew approachesnovel approachesnovel strategiesnovel strategypathophysiologypatients infected with AIDSpatients with AIDSpatients with acquired immunodeficiency syndromepreventpreventingprogramspromoterpromotorreceptorregional enteritisrenalrheumatic arthritissocial rolesystemic lupus erythematosisvisual function
Description preview
Program Summary
Progressive Multifocal Leukoencephalopathy (PML) is a major life threatening complication in patients
with AIDS and in patients undergoing immunotherapy for autoimmune diseases such as multiple
sclerosis, Crohn's disease, severe plaque psoriasis, systemic lupus erythematosis, hematologic
malignancies, and rheumatoid arthritis. The…
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