grant
PROgression of Tuberculosis infECTion in young children living with and without HIV: the PROTECT study
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20260-11 years old21+ years old5 year old5 years of ageAIDS VirusAccuracy of DiagnosisAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAcuteAddressAdolescentAdolescent YouthAdultAdult HumanAntibodiesAntibody ResponseAntigen-Antibody ComplexAntigensAssayB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBioassayBioinformaticsBiologicalBiological AssayBiological MarkersBlood BanksBlood Plasma CellBody TissuesCandidate Disease GeneCandidate GeneCell BodyCell DeathCellsCessation of lifeCharacteristicsChildChild YouthChildhoodChildren (0-21)ClinicalCountryDeathDiseaseDisease ProgressionDisorderEarly DiagnosisEarly treatmentEvaluationExpression SignatureFundingGambiaGene Expression ProfileGene TranscriptionGeneralized GrowthGenesGenetic TranscriptionGrowthHIVHIV in childrenHIV in pediatric populationsHIV infected childrenHIV positive childrenHIV+ childrenHRMSHuman Immunodeficiency VirusesImmuneImmune ComplexImmunesImmunochemical ImmunologicImmunologicImmunologic SensitizationImmunologicalImmunological SensitizationImmunologicallyImmunologicsIn VitroInfectionInjuryLAV-HTLV-IIILinkLymphadenopathy-Associated VirusM tbM tuberculosisM tuberculosis antigenM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis antigenM. tuberculosis infectionM.tb antigenM.tb infectionM.tuberculosis infectionMTB infectionMachine LearningMeasuresMouse StrainsMtb antigenMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis antigensMycobacterium tuberculosis infectionNIAIDNational Institute of Allergy and Infectious DiseaseNetwork AnalysisNon-Polyadenylated RNAPathogenesisPathway AnalysisPathway interactionsPerformancePhIP-seqPhage ImmunoPrecipitation SequencingPlasma CellsPlasmacytesPredictive ValuePreventative therapyPreventative treatmentPreventive therapyPreventive treatmentProteinsProteomeProteomicsRNARNA ExpressionRNA Gene ProductsRecommendationResearchRibonucleic AcidRoleSamplingSecondary toSouth AfricaSpecific qualifier valueSpecifiedSubgroupSystemTB diagnosisTB immunityTB infectionTestingTherapy trialTissue GrowthTissuesTrainingTranscriptionTranslatingTuberculosisTuberculosis diagnosisUgandaUrineViet NamVietnamViral Respiratory Tract InfectionVirus-HIVWhole BloodWorld Health Organizationadulthoodage 5age 5 yearsbio-informatics pipelinebio-markersbiobankbioinformatics pipelinebiologicbiologic markerbiomarkerbiomarker arraybiomarker discoverybiomarker identificationbiomarker panelbiomarker signaturebiorepositorybiosignaturecandidate biomarkercandidate identificationcandidate markerchildhood HIVchildren infected with HIVchildren living with HIVchildren living with human immunodeficiency viruschildren with HIVclinical relevanceclinical validationclinically relevantcohortdiagnosed with TBdiagnosed with Tuberculosisdiagnostic accuracydisseminated TBdisseminated tuberculosisearly detectionearly therapyfield based datafield learningfield studyfield testfive year oldfive years of agegene expression patterngene expression signaturehigh resolution mass spechigh resolution mass spectrometryhigh resolution mass spectroscopyhigh riskhigh-resolution mass spectrometerhuman modelidentification of biomarkersidentification of new biomarkersimmunity against M. tuberculosisimmunity against Mtbimmunity against Mycobacterium tuberculosisimmunity against TBimmunity against tuberculosisimmunity in tuberculosisimmunity to TBimmunity to tuberculosisimmunogenimmunopathologyin vivoinfection due to Mycobacterium tuberculosisinjuriesinjury to tissueinsightion mobilityjuvenilejuvenile humankidsmachine based learningmarker identificationmarker panelmetabolism measurementmetabolomicsmetabonomicsmodel of humanmouse modelmtbmultiomicsmultiple omicsmurine modelmycobacterialnecrocytosisnew markernext generationnovelnovel biomarkernovel markerontogenypanomicspathwaypediatricpediatric HIVpediatric human immunodeficiency viruspediatric populations infected with HIVplasmocytepoint of carepoint of care testingresponsescale upsegregationsocial roletargeted biomarkertissue injurytranscriptional profiletranscriptional signaturetuberculosis immunitytuberculosis infectiontuberculous spondyloarthropathyviral respiratory infectionyoungster
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PROJECT SUMMARY
The vast majority of child tuberculosis (TB) deaths occur in children <5 years old, highlighting the importance of
identifying young children at high risk of developing TB and initiating preventive treatment. However, current
tests for Mycobacterium tuberculosis (Mtb) infection have poor predictive value for TB progression. To make…
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