grant
Programs for generating inhibitory interneuron diversity and connectivity
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 20 Mar 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2025AD dementiaASDAccelerationActivities of Daily LivingActivities of everyday lifeAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAssayAutismAutistic DisorderBar CodesBasal Transcription FactorBasal transcription factor genesBioassayBiological AssayBrainBrain Nervous SystemCell BodyCell Communication and SignalingCell Migration AssayCell SignalingCell TherapyCellsCellular MorphologyClassification SchemeCodeCoding SystemCollaborationsComplexConnector NeuronCyclicityDataDegenerative Neurologic DisordersDevelopmentDiseaseDisorderDissociationDoxycyclineDysfunctionEarly Infantile AutismEncephalonEndowmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpilepsyEpileptic SeizuresEpilepticsFibroblastsFunctional disorderGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGeneticGenetic RiskGenetic TranscriptionGenetic studyGenomicsGoalsHigh Throughput AssayHumanImageIn VitroIndividualInduced NeuronsInfantile AutismIntercalary NeuronIntercalated NeuronsInterdisciplinary ResearchInterdisciplinary StudyInterneuron functionInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingKanner's SyndromeLabelLibrariesLineage TracingLinkLogicMethodsMiceMice MammalsMigration AssayModern ManMolecular AnalysisMorphologyMotilityMultidisciplinary CollaborationMultidisciplinary ResearchMurineMusNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuronsOutcomeOutputPatternPeriodicityPhenotypePhysiopathologyPopulationPopulation HeterogeneityPositionPositioning AttributePrimary Senile Degenerative DementiaProductionRNA ExpressionReproducibilityResearch ResourcesResourcesRhythmicitySchizophreniaSchizophrenic DisordersSeizure DisorderSignal TransductionSignal Transduction SystemsSignalingSpecific qualifier valueSpecificitySpecifiedSynapsesSynapticTechnologyTest ResultTestingTherapeuticTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransplantationVibramycinalpha-6-Deoxyoxytetracyclineautism spectral disorderautism spectrum disorderautistic spectrum disorderbarcodebasebasesbiological signal transductioncell based interventioncell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell mediated interventioncell mediated therapiescell morphologycell typecell-based therapeuticcell-based therapycellular lineage mappingcellular lineage trackingcellular therapeuticcellular therapycombinatorialdaily living functiondaily living functionalitydegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdementia praecoxdevelopmentaldisease modeldisease riskdisorder modeldisorder riskdiverse populationsepigeneticallyepilepsiaepileptogenicfunctional abilityfunctional capacitygain of functiongene regulatory networkglobal gene expressionglobal transcription profileheterogeneous populationhigh throughput screeningiNeuroniPSiPSCiPSCsimagingimprovedin vivoinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinhibitory neuronintercalationmachine learning based methodmachine learning methodmachine learning methodologiesmigrationmulti-modalitymultimodalityneural circuitneural circuitryneural degenerationneurocircuitryneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronalneuronal degenerationneuropsychiatric diseaseneuropsychiatric disordernovelpathophysiologypopulation diversityprimary degenerative dementiaprogramsrepairrepairedscRNA sequencingscRNA-seqschizophrenicscreeningscreeningssenile dementia of the Alzheimer typesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsynapsesynapse formationsynaptic circuitsynaptic circuitrysynaptogenesistooltranscription factortranscriptometranscriptomicstransplanttransplant model
Description preview
SUMMARY:
Inhibitory interneurons comprise a diverse class of neurons of indisputably high biomedical importance.
Interneuron dysfunctions are linked to neuropsychiatric disorders such as autism and schizophrenia and are also
implicated in epilepsy and neurodegeneration. Cortical interneurons are born in the ganglionic eminences. As
they develop,…
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