grant
Programming cellular behavior by mechanical forces
NIHUS FederalResearch GrantFY2025AffectAntigensAntitumor ResponseBasic ResearchBasic ScienceBindingBiochemicalBiologic FactorBiological FactorsBiological FunctionBiological ProcessBiologyCancer TreatmentCancersCatalytic RNACategoriesCell AdhesionCell BodyCell CommunicationCell Communication and SignalingCell DifferentiationCell Differentiation processCell FunctionCell InteractionCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCell SignalingCell TherapyCell-Extracellular MatrixCell-to-Cell InteractionCellsCellular AdhesionCellular FunctionCellular MechanotransductionCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCellular biologyChemicalsChromatinChromosomal SynapsisChromosome PairingChromosome SegregationComplementComplement ProteinsDNA TherapyDevelopmentDevicesDiseaseDisorderDrug TherapyECMElementsEngineeringEnvironmentEventExtracellular MatrixFibroblastsFoundationsGene ExpressionGene Transfer ClinicalGenetic InterventionHealthImmune Cell ActivationImmune responseIntracellular Communication and SignalingLigandsM PhaseMHC ReceptorMajor Histocompatibility Complex ReceptorMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMechanical Signal TransductionMechanicsMechanosensory TransductionMediatingMediatorMessenger RNAMissionMitosisMitosis StageMitotic spindleMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMonitorMorphogenesisNational Institutes of HealthNatural regenerationNon-Polyadenylated RNAOrganOutputPeptide DomainPeptide-MHCPeptide-Major Histocompatibility Protein ComplexPeptide/MHC ComplexPeptidesPharmacological TreatmentPharmacotherapyPlayProcessProductionPropertyProtein DomainsProtein EngineeringProteinsRNARNA BindingRNA Gene ProductsRNA boundReceptor ActivationRegenerationResearchRibonucleic AcidRibozymesRoleSignal TransductionSignal Transduction SystemsSignalingStimulusSubcellular ProcessSynapsisSystemT-Cell Antigen ReceptorsT-Cell ProliferationT-Cell ReceptorT-CellsT-LymphocyteTechnologyTertiary Protein StructureTherapeuticTransducersUnited States National Institutes of HealthWorkanti-cancer immunotherapyanti-cancer therapyanti-tumor responseanticancer immunotherapybiological signal transductioncancer immunotherapycancer therapycancer-directed therapycell based interventioncell behaviorcell biologycell engineeringcell mediated interventioncell mediated therapiescell motilitycell-based therapeuticcell-based therapycellular behaviorcellular differentiationcellular engineeringcellular therapeuticcellular therapychromosome divisioncomplementationconformationconformationalconformational stateconformationallyconformationsdevelopmentaldigitaldisabilitydrug interventiondrug treatmentexhaustionexperimentexperimental researchexperimental studyexperimentsextracellularforce sensorgene repair therapygene therapygene-based therapygenetic protein engineeringgenetic therapygenomic therapyhost responseimmune activationimmune system responseimmune-based cancer therapiesimmunogenimmunoresponseimmunotherapy for cancerimmunotherapy of cancerimprovedinnovateinnovationinnovativeinsightinterestmRNAmalignancymechanicmechanicalmechanical cuemechanical forcemechanical signalmechanosensingmechanotransductionmorphogenetic processneoplasm/cancernew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapypMHCpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprogenitor cell differentiationprogenitor differentiationprogramsprotein designprotein expressionreceptor bindingreceptor boundregenerateregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueregeneration based therapyregeneration therapyregenerative therapeuticsregenerative therapyresponsesensorsocial rolestem and progenitor differentiationstem cell differentiationsynthetic biologytherapeutic agent developmenttherapeutic developmentthymus derived lymphocytetissue regenerationtissue regrowthtissue renewaltissue specific regenerationtumorvirtual
Description preview
ABSTRACT
Cellular behaviors are modulated by a variety of stimuli in the environment, which can be generally categorized
as chemical, physical, and biological factors. Previous work suggests that physical forces, both at the mesoscale
of cell-cell interactions and the microscale of ligand-receptor binding events, play a critical role in regulating…
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