grant
Programmable Hydrogels for Optimized Human Oligodendrocyte Transplantation in Demyelinating Disease
Organization STATE UNIVERSITY OF NEW YORK AT BUFFALOLocation AMHERST, UNITED STATESPosted 1 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AccelerationAddressAlloantibodiesAlloantigenAnimal ModelAnimal Models and Related StudiesApoptosisApoptosis PathwayAreaBiocompatible MaterialsBiologicalBiomaterialsBiomedical EngineeringBody TissuesBrainBrain Nervous SystemCNS Nervous SystemCell BodyCell DeathCell Fate ControlCell Fate RegulationCell Growth and MaintenanceCell MaintenanceCell SurvivalCell TherapyCell TransplantationCell ViabilityCellsCentral Nervous SystemClinical TreatmentCorpus CallosumCorpus CallosumsCuesDataDegenerative Neurologic DisordersDemyelinating DiseasesDemyelinating DisordersDemyelinationsDevelopmentDiseaseDisorderDisseminated SclerosisDomestic RabbitEncephalonEnvironmentFormulationGliaGlial CellsGoalsGrantGrowth AgentsGrowth FactorGrowth SubstancesHumanHydrogelsImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInflammationInjectionsInjuryIschemiaIsoantibodiesKolliker's reticulumLaboratoriesLeannessMaintenanceMediatingMethodsMiceMice MammalsModelingModern ManMultiple SclerosisMurineMusMyelinNervous System Degenerative DiseasesNervous System PhysiologyNeural Degenerative DiseasesNeural Stem CellNeural degenerative DisordersNeuraxisNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeurologic Degenerative ConditionsNeurologic functionNeurological functionNeurosciencesNon-neuronal cellNonneuronal cellOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellOperative ProceduresOperative Surgical ProceduresOryctolagus cuniculusOutcomePeptidesPreparationProgenitor Cell TransplantationProgrammed Cell DeathProliferatingProteins Growth FactorsRabbitsRabbits MammalsRegenerative MedicineRodentRodentiaRodents MammalsSeriesSiteSpinal Cord DiseasesSpinal Cord DisordersSpinal Cord TraumaSpinal TraumaSpinal cord injuredSpinal cord injuryStem Cell TransplantationStem cell transplantSurgicalSurgical InterventionsSurgical ProcedureTestingThinnessTissuesTranslationsTransplantationTraumatic MyelopathyWorkanimal model developmentbio-engineeredbio-engineersbioengineeringbiologicbiological engineeringbiological materialcell based interventioncell mediated interventioncell mediated therapiescell preparationcell replacement therapycell replacement treatmentcell-based therapeuticcell-based therapycellular therapeuticcellular therapycellular transplantchronic demyelinationclinical interventionclinical therapyde-myelinating diseasesde-myelinating disordersdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdemyelinatedemyelinating conditionsdemyelination diseasesdemyelination disordersdesigndesigningdevelopmentalhuman diseasehydrogel scaffoldimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimplantationimprovedimproved outcomein vivoinjuredinjuriesinnovateinnovationinnovativeinsular sclerosismechanical propertiesminimally invasivemodel of animalmyelinationmyelopathynecrocytosisnerve cementnerve stem cellnervous system functionneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurodegenerative illnessneurogenic progenitorsneurogenic stem cellneuron progenitorsneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitornew approachesnovelnovel approachesnovel strategiesnovel strategypreparationspreventpreventingprogenitor and neural stem cellsprogenitor cell deliveryprogenitor cell fateprogenitor cell survivalprogenitor deliveryprogenitor fateprogenitor survivalprogenitor transplantationre-myelinatere-myelinationregeneration based therapyregeneration therapyregenerative therapeuticsregenerative therapyremyelinateremyelinationrepairrepairedshear stressstem and progenitor cell fatestem and progenitor cell transplantationsstem cell deliverystem cell fatestem cell survivalsurgerytranslationtranslation strategytranslational approachtranslational strategytransplanttrial regimentrial treatment
Description preview
ABSTRACT
Some of the most devastating neurodegenerative diseases such as multiple sclerosis, are characterized by
chronic demyelination and a tissue environment that prevents efficient myelin repair and remyelination. While
cell therapies have the potential to promote remyelination and restore lost neurological function, major barriers
remain that…
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