grant
Programmable DNA Nanostructures as Biomedical and Structural Scaffolds
Organization STATE UNIVERSITY OF NEW YORK AT ALBANYLocation ALBANY, UNITED STATESPosted 1 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressAdoptedAntibodiesAreaAwardBindingBioavailabilityBiodistributionBiologicalBiological AvailabilityBiosensing TechnicsBiosensing TechniquesBody SystemCell BodyCell Culture TechniquesCellsChemicalsCrystallizationCrystallographiesCrystallographyDNADataDeoxyribonucleic AcidDevelopmentDiseaseDisorderDrug CarriersDrug DeliveryDrug Delivery SystemsDrug ScreeningDrugsDystrophia myotonica type 1FaceFreezingHealthImmune responseInvestigatorsLigandsMedicationMethodsMinor GrooveModificationMolecular InteractionMyotonic dystrophy type 1NIGMSNanostructuresNanotechnologyNational Institute of General Medical SciencesOligoOligonucleotidesOrgan SystemPeptidesPharmaceutical PreparationsPhysiologic AvailabilityPolycyclic CompoundsPositionPositioning AttributeProteinsRadiation induced damageResearchResearch PersonnelResearchersResolutionRoentgen RaysScaffolding ProteinSingle Crystal DiffractionStructureSystemic diseaseToxic effectToxicitiesUse of New TechniquesValidationWorkX Ray CrystallographiesX-RadiationX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray RadiationX-Ray/Neutron CrystallographyX-rayXrayXray CrystallographyXray free electron laserapplication in practicebio-imagingbioimagingbiologicbiosensingcell culturecell culturesdesigndesign and constructdesign and constructiondesigningdevelopmentaldrug candidatedrug/agentfacesfacialfluorophorehost responseimmune system responseimmunoresponseimprovedmouse modelmurine modelnano particlenano technano technologynano-sized particlenano-sized structuresnano-structuresnano-technologicalnanoparticlenanosized particlenanotechnanotechnologicaloligospractical applicationpre-clinicalpreclinicalradiation damageresolutionsscaffoldscaffoldingscreeningscreeningsself assemblytechnology platformtechnology systemthree dimensionalvalidationsx-ray FELx-ray free-electron laser
Description preview
PROJECT ABSTRACT/SUMMARY
DNA nanotechnology offers near-atomic control for building structures, with precise positioning of guest
molecules such as antibodies, fluorophores and ligands that make them potentially useful in a number of
biological applications such as biosensing, drug delivery, cell modulation and bioimaging. However, there are
still…
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