grant
Program control of CD8+ T cell response to tumors and tumor memory
Organization H. LEE MOFFITT CANCER CTR & RES INSTLocation TAMPA, UNITED STATESPosted 13 Aug 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2026ATAC sequencingATAC-seqATACseqAblationAdoptive Cell TransfersAntineoplastic VaccineAntitumor ResponseAssay for Transposase-Accessible Chromatin using sequencingBasal Transcription FactorBasal transcription factor genesBiologyCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCancer PatientCancer VaccinesCell BodyCellsCharacteristicsChromatinClinicalComplexDataDependenceEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExposure toFailureFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGenetic TranscriptionGenomicsHeterogeneityHistonesHumanHypoxiaHypoxicImmuneImmune mediated therapyImmune responseImmunesImmunologically Directed TherapyImmunotherapyInfiltrationKnowledgeLEF Transcription FactorLYT3Lymphoid Enhancer FactorMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant Tumor of the OvaryMalignant neoplasm of ovaryMelanoma TumorMemoryMiceMice MammalsModelingModern ManMurineMusNeoplasm VaccinesNewly DiagnosedOncologyOncology CancerOutcomeOvarian TumorOvary CancerOvary NeoplasmsOvary TumorOxygen DeficiencyPathway interactionsPatientsPhenotypePlayPopulationPositionPositioning AttributePrediction of Response to TherapyRNA ExpressionRecurrenceRecurrentRecurrent NeoplasmRecurrent tumorRelapseResearchResistanceRoleSamplingSolid NeoplasmSolid TumorSpleenSpleen Reticuloendothelial SystemStem Cell likeSystems BiologyT Cell FactorT cell responseT memory cellT8 CellsT8 LymphocytesTCF Transcription FactorTherapeuticTherapeutic InterventionTimeTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTumor BurdenTumor LoadTumor VaccinesTumor growth in melanomaTumor-Infiltrating Lymphocytesadoptive cell therapyadoptive cellular therapyanti-tumor immune responseanti-tumor responseanti-tumor vaccineassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingcancer progressioncheck point blockadecheckpoint blockadedimensional analysisdraining lymph nodeepigeneticallyepigenomeepigenomicsexhaustexhaustionflow cytophotometrygene regulatory networkgenome scalegenome-widegenomewidehigh dimensionalityhost responsehuman cancer mouse modelimmune check point blockadeimmune checkpoint blockadeimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunoresponseimprovedintervention therapymemory T lymphocytemulti-modalitymultimodalityneoplasm progressionneoplasm recurrenceneoplastic progressionovarian cancerovarian neoplasmpathwaypredict responsivenesspredict therapeutic responsepredict therapy responsepredicting responseprogenitorprogenitor capacityprogenitor cell likeprogenitor-likeprogramsproliferation capabilityproliferation capacityproliferation potentialproliferative capabilityproliferative capacityproliferative potentialregional lymph noderesistantresponders and non-respondersresponders from non-respondersresponders or non-respondersresponders versus non-respondersresponders vs non-respondersresponders/nonrespondersresponseresponse to therapyresponse to treatmentscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestem cell characteristicsstem-likestemnesssuccesstherapeutic responsetherapy predictiontherapy responsetranscription factortreatment predictiontreatment responsetreatment response predictiontreatment responsivenesstumortumor behaviortumor progressionvaccine for cancer
Description preview
Abstract
CD8+ tumor infiltrating lymphocytes (TILs) are not only critical for the anti-tumor immune response in solid
tumors, but also in the success of adoptive cell therapies and in immune check point blockade (ICB) treatments.
CD8+ TILs have been shown to be heterogeneous, and in time to progress to a terminally exhausted state, with
no ability…
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