grant
Profiling Translation in Nociceptor Plasticity
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 15 Sept 2020Deadline 31 May 2030
NIHUS FederalResearch GrantFY202521+ years old5' Untranslated Regions5'UTRATF-4AddressAdultAdult HumanAfferent NeuronsAnalgesia TestsAnzataxAsotaxBehaviorBehavioralBody TissuesBristaxolCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyDataDetectionDorsal Root GangliaEIF-2EIF2Eukaryotic Initiation Factor-2Eukaryotic Peptide Initiation Factor-2Gene TranscriptionGenesGeneticGenetic TranscriptionGenomic approachGoalsHealth Care SystemsHumanHypersensitivityInflammation MediatorsInstructionKinasesKnowledgeLifeLong-term painMessenger RNAMiceMice MammalsModalityModelingModern ManMolecularMolecular TargetMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuronsNociceptionNociception TestsNociceptorsNucleotidesORFsOpen Reading FramesOutcomeOutputPaclitaxelPaclitaxel (Taxol)PainPain AssessmentPain ControlPain MeasurementPain TherapyPain managementPain measurePainfulPathway interactionsPeptide Initiation Factor EIF-2Persistent painPhenotypePhosphorylationPhosphotransferase GenePhosphotransferasesPhysiologyPraxelProcessProtacProtein BiosynthesisProtein Coding RegionProtein PhosphorylationProtein Synthesis AntagonistsProtein Synthesis InhibitorsProteinsProteolysis targeting chimericQOLQuality of lifeRNA ExpressionRegulationRepressionRibo-seqRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRodentRodentiaRodents MammalsRoleSensory NeuronsSpecificitySpinal GangliaTaxolTaxol ATaxol KonzentratTestingTissuesTranscriptionTransfer RNATransfer RNA AcylationTransfer RNA Amino AcylationTransfer RNA AminoacylationTransfer RNA ChargingTranslational RegulationTranslationsTransphosphorylasesTriplet Codon-Amino Acid AdaptorValidationWorkactivating transcription factor 4adulthoodallodyniabiological adaptation to stresschronic painconstant paindorsal root gangliondosageexperimentexperimental researchexperimental studyexperimentsfunctional genomicsgenomic effortgenomic strategygenomic toolsglobal gene expressionglobal transcription profileimprovedin vivoinflammatory mediatorinhibitorinsightlasting painmRNAmRNA ExpressionmRNA Leader SequencesmRNA Translationneuronalneuronal excitabilityneuropathic painnociceptivenociceptive neuronsnovelon-going painongoing painpain assaypain interventionpain signalpain treatmentpain-sensing neuronspain-sensing sensory neuronspain-sensing somatosensory neuronspainful neuropathypathwaypharmacologicposttranscriptionalprotein synthesisproteolysis targeting chimaeraproteolysis targeting chimerareaction; crisisresponseribosome footprint profilingribosome profilingsocial rolespontaneous painstress responsestress; reactiontRNAtRNA AcylationtRNA Amino AcylationtRNA AminoacylationtRNA Chargingtranscriptometransfer Ribonucleic acidstranslationupstream kinasevalidationsvirtual
Description preview
PROJECT SUMMARY/ABSTRACT
Chronic pain is pervasive and devastating. It diminishes quality of life for 20% of adults. An integral feature of
persistent pain is increased excitability in nociceptive sensory neurons. The molecular mechanisms that
orchestrate plasticity in nociceptors are unclear.
The integrated stress response (ISR) is a master…
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