grant
Production of Cultured Red Blood Cells
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 15 Sept 2015Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY202521+ years oldAbscissionAddressAdultAdult HumanAlbuminsAlloantibodiesAlloimmunizationAnimal ModelAnimal Models and Related StudiesAntibodiesAntigensBioreactorsBlood Precursor CellBlood donorBlood erythrocyteBlood reticulocyteC-KIT GeneCD117CD117 AntigensCD34CD34 geneCell BodyCell Communication and SignalingCell DensityCell LineCell NucleusCell SignalingCell SizeCellLineCellsCharacteristicsChemicalsChronicClinical Medical SciencesClinical MedicineClinical TrialsCollaborationsComplexComplicationCord BloodCultural CharacteristicsDNA mutationDevelopmentDiagnosticDiffusely basophilic erythrocyteDiseaseDisorderDysmyelopoietic SyndromesEC 2.7.7.49EffectivenessEmbryoEmbryonicErythroblastsErythrocyte TransfusionErythrocytesErythrocyticExcisionExtirpationFiberGeneralized GrowthGenerationsGenetic ChangeGenetic defectGenetic mutationGrowthHPCA1Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene HomologHb SS diseaseHbSS diseaseHematopoieticHematopoietic Progenitor CellsHematopoietic stem cellsHemoglobinHemoglobin S DiseaseHemoglobin sickle cell diseaseHemoglobin sickle cell disorderHumanIn VitroIntracellular Communication and SignalingIsoantibodiesJAK-2JAK2JAK2 geneJAK2 proteinJanus kinase 2KIT geneMarrow erythrocyteMarrow reticulocyteMast Cell Growth Factor ReceptorMethodsModern ManMorphologyMutationMyelodysplastic DiseaseMyelodysplastic SyndromesNatureNormoblastsNucleated ErythrocytesNucleated red blood cellNucleated red cellNucleusOncogene KITPatientsPlayPolychromatophilic ErythrocyteProcessProductionProliferatingProto-Oncogene Protein c-kitProtocolProtocols documentationRNA TranscriptaseRNA-Dependent DNA PolymeraseRNA-Directed DNA PolymeraseReagentRed Blood Cell TransfusionRed Blood CellsRed CellRefractory Anemia with an Excess of BlastsRefractory anaemia with excess blastsRemovalReproducibilityReticulocytesReverse TranscriptaseRevertaseRoleSCF ReceptorSCF Receptor GeneSCFRSickle CellSickle Cell AnemiaSignal TransductionSignal Transduction SystemsSignalingSmoldering LeukemiaSourceStem Cell Factor ReceptorStem Cell Factor Receptor GeneStrains Cell LinesSurgical RemovalSystemTechnologyTelomeraseTestingTissue GrowthTransfusionTranslatingTyrosine-Protein Kinase JAK2Umbilical Cord Bloodadulthoodbiological signal transductionblood cell progenitorblood corpusclesblood progenitorblood stem cellblood-forming stem cellc kitc-kit Proteinc-kit Receptorcell immortalizationcostcost effectivecultured cell linecytokinedensitydevelopmentalexperimentexperimental researchexperimental studyexperimentsfetal cord bloodfull scale manufacturinggenome mutationhematopoietic progenitorhematopoietic stem progenitor cellhemopoietichemopoietic progenitorhemopoietic stem celliPSiPSCiPSCsimmunogenimprovedin vivoinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinnovateinnovationinnovativekit Proto-Oncogene Proteinlarge scale manufacturinglarge scale productionmass productionmicrobioreactormodel of animalmyelodysplasianovelnucleated RBCsontogenyoverexpressoverexpressionp145(c-kit)p145c-kitperipheral bloodprogenitorproliferation capabilityproliferation capacityproliferation potentialproliferative capabilityproliferative capacityproliferative potentialresectionself renewing cellself-renewself-renewalsenescencesenescentsickle RBCsickle cell diseasesickle cell disordersickle diseasesickle erythrocytesickle red blood cellsicklemiasocial rolestemtransfusion medicine
Description preview
Summary:
We have developed an innovative and highly efficient method for producing enucleated cultured Red Blood Cells (cRBCs)
from induced Pluripotent Stem cells (iPSCs). This method involves introducing specific genetic mutations, the D816V
mutation in the kit gene (SCF receptor) and the V617F mutation in the Jak2 gene, resulting in the…
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