grant
Probing the role of serotonin in neuropathic pain with flexible carbon microelectrode arrays
Organization LOUISIANA TECH UNIVERSITYLocation RUSTON, UNITED STATESPosted 1 Jun 2022Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20265-HT5-HT(2C) Receptor5-HT2C Receptor5-Hydroxytryptamine5-Hydroxytryptamine Type 2C Receptors5HTAcidsAcuteAdhesionsAffectAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnatomic SitesAnatomic structuresAnatomyAnodynesAntinociceptive AgentsAntinociceptive DrugsAreaBiologicalBody TissuesBuckytubesCarbonCarbon NanotubesCarbon nano tubesCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsChronicChronic PhaseCognitionCyclicityDataDetectionDevelopmentDevicesDrugsE-stimElectric StimulationElectrodesElectrophysiologyElectrophysiology (science)EnteramineFailureFilmFluoxamineFluvoxamineGeneticGlassH2O2HippophaineHistologicHistologicallyHybridsHydrogen PeroxideHydroperoxideImplantInfusionInfusion proceduresInjuryIntracellular Communication and SignalingLeannessLearningLinkMaintenanceMeasurementMeasuresMechanicsMedicationMemoryMetalsMiceMice MammalsMicrodialysisMicroelectrodesMiniaturized ElectrodesModelingMonitorMoodsMorphologyMurineMusNervous SystemNeurologic Body SystemNeurologic Organ SystemNeuropathyNeurophysiology / ElectrophysiologyNucleusPainPainfulPatternPerformancePeriodicityPharmaceutical PreparationsPhasePolymersProcessPropertyProtocolProtocols documentationReceptor ProteinRewardsRhythmicityRodentRodentiaRodents MammalsRoleRunningSSRISSRIsSalineSaline SolutionScanningSelective Serotonin Reuptake InhibitorSelective serotonin re-uptake inhibitorSerotoninSerotonin 2C ReceptorSerotonin Receptor 5-HT2CSignal TransductionSignal Transduction SystemsSignalingSiteSurfaceTechnologyTestingTherapeuticThinnessTimeTissuesTrace metalamygdaloid nuclear complexanti-depressant agentanti-depressant drugsanti-depressantsanti-depressive agentsbiologicbiological signal transductionchronic painchronic pain controlchronic pain interventionchronic pain managementchronic pain therapychronic pain treatmentclinical efficacydesigndesigningdetection sensitivitydevelopmentaldrug/agentelectrophysiologicalelectrostimulationexperimentexperimental researchexperimental studyexperimentsextracellularfabricationflexibilityflexibleimplantable sensorimplantationimplanted sensorimprovedin vivoinfusionsinjuriesinterestmechanicmechanicalmouse modelmulti-electrode arraysmultielectrode arraysmurine modelnerve injuryneuralneural injuryneuropathicneuropathic painnovelpain killerpain medicationpain reductionpain relieverpainful neuropathypainkillerpolymerpolymericpreventpreventingreceptorreduce painresponsesensorserotonin reuptake inhibitorsocial rolespared nervetechnology implementationtechnology platformtechnology systemtechnology validationtooltreat chronic pain
Description preview
PROJECT SUMMARY
Antidepressants have been front-line treatments for chronic pain for years. However, clinical efficacy of
selective serotonin reuptake inhibitors (SSRI’s) has been moderate and highly variable across different
conditions, which calls for a deeper understanding of 5-HT’s role in modulating pain, in an anatomical and…
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