grant
Probing protein structure and aggregation in complex environments with 2D IR spectroscopy
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY20252-dimensionalAD dementiaAD pathologyAdsorptionAffectAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's disease pathologyAlzheimer's pathologyAlzheimers DementiaAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAβBiologic ModelsBiologicalBiological ModelsCerebrospinal FluidChemistryComplexCristobaliteDiseaseDisorderEnvironmentGoalsHealthHumanIn VitroLabelLysozymeMachine LearningMapsMeasuresMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMethodsModel SystemModelingModern ManMuramidaseN-Acetylmuramide GlycanhydrolaseOrganismPathway interactionsPeptidesPeptidoglycan N-acetylmuramoylhydrolasePhysiologicPhysiologicalPrimary Senile Degenerative DementiaProtein DynamicsProteinsResearchResolutionRoleSandSilicaSilicon DioxideSiteSpectroscopySpectrum AnalysesSpectrum AnalysisStructureSurfaceSurface ProteinsSystemTimeTridymitea beta peptideabetaabeta accumulationabeta aggregationamyloid betaamyloid beta accumulationamyloid beta aggregationamyloid β accumulationamyloid β aggregationamyloid-b proteinaβ accumulationaβ aggregationbeta amyloid fibrilbiologiccerebral spinal fluiddesigndesigningfunctional groupimprovedinsightinsoluble aggregateliving systemmachine based learningmetallicitynano particlenano-sized particlenanomaterialsnanoparticlenanoparticle exposurenanosized particlenon-natural amino acidsnon-proteinogenic amino acidsnonproteinogenic amino acidspathwayprimary degenerative dementiaprogramsprotein aggregateprotein aggregationprotein complexprotein structureprotein structuresproteins structureresolutionsresponseself assemblysenile dementia of the Alzheimer typesocial rolesoluble amyloid precursor proteinspinal fluidtwo-dimensionalunnatural amino acids
Description preview
The goal of our proposed research program is to develop new spectroscopic methods capable of
providing enhanced insight into protein structure and dynamics within complex environments that
impact human health. We will apply these methods to study structural changes induced by
protein-protein and protein-surface interactions under conditions that…
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