grant
Primate inhibitory neurons in hippocampal CA3-CA1 intrinsic circuits
Organization BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)Location BOSTON, UNITED STATESPosted 1 Apr 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2025Action PotentialsAffectAffectiveAffective DisordersAmmon HornAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnimal ModelAnimal Models and Related StudiesAnteriorAnxietyAnxiety DisordersAxonBiologic ModelsBiological ModelsBiophysicsBrain regionCCKCalcium-Binding ProteinsCell BodyCell Communication and SignalingCell SignalingCellsCholecystokininCognitionCognitiveCommon Rat StrainsCommunitiesComplexComputer ModelsComputerized ModelsConfocal MicroscopyCornu AmmonisCyclic SomatostatinDataData BasesDatabasesDendritesDevelopmentDimensionsDiseaseDisinhibitionDisorderDysfunctionEDRF SynthaseElectron MicroscopyElectrophysiologyElectrophysiology (science)ElementsEmotionsEndothelium-Derived Growth Factor SynthaseEntorhinal AreaEvolutionExhibitsFunctional disorderGoalsGrowth Hormone Inhibiting FactorsGrowth Hormone-Inhibiting HormoneGuanylyl Cyclase-Activating Factor SynthaseHippocampusHumanHyperactivityIn VitroIntracellular Communication and SignalingLearningLiteratureLocationM mulattaM. mulattaMacaca mulattaMacaca rhesusMeasuresMediatingMemoryMental disordersMental health disordersMiceMice MammalsModel SystemModelingModern ManMood DisordersMorphologyMurineMusNO SynthaseNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeuropeptide TyrosineNeurophysiology / ElectrophysiologyNitric Oxide SynthaseNitric-Oxide SynthetasePHM27PTSDPancreozyminParvalbuminsPathway interactionsPeptidesPhylogenyPhysiologicPhysiologicalPhysiologyPhysiopathologyPost-Traumatic NeurosesPost-Traumatic Stress DisordersPosttraumatic NeurosesPredispositionPrefrontal CortexPrimatesPrimates MammalsProcessPropertyPsychiatric DiseasePsychiatric DisorderPublishingPyramidal neuronRatRats MammalsRattusResearchResolutionRhesus MacaqueRhesus MonkeyRodentRodentiaRodents MammalsRoleSRIHSRIH-14SchizophreniaSchizophrenic DisordersSignal TransductionSignal Transduction SystemsSignalingSiteSomatostatinSomatostatin-14Somatotropin Release Inhibiting FactorsSomatotropin Release-Inhibiting HormoneStaining methodStainsSusceptibilitySynapsesSynapticSystemTestingThalamic structureThalamusUropancreozyminVasoactive Intestinal PeptideVasoactive Intestinal PolypeptideVasointestinal PeptideWorkadaptive learningamygdaloid nuclear complexbiological signal transductionbiophysical analysisbiophysical characteristicsbiophysical characterizationbiophysical foundationbiophysical measurementbiophysical parametersbiophysical principlesbiophysical propertiesbiophysical sciencesbiophysical studiescalbindincalbindin 2calretininclinical relevanceclinically relevantcomputational modelingcomputational modelscomputer based modelscomputerized modelingconfocal imagingdata basedementia praecoxdevelop therapydevelopmentaleffective therapyeffective treatmentelectrophysiologicalentorhinal cortexfallsgrowth hormone release inhibiting factorhippocampalhippocampal pyramidal neuroninhibitory neuroninnervationinnovateinnovationinnovativeinsightintervention developmentmental illnessmodel of animalmulti-modalitymultimodalitynerve supplyneurochemicalneurochemistryneuronalneuropeptide Ynovelpathophysiologypathwayphysiologic modelpost-trauma stress disorderpostsynapticposttrauma stress disorderpsychiatric illnesspsychological disorderresolutionsschizophrenicsocial rolesynapsethalamictherapy developmenttraumatic neurosistreatment development
Description preview
Abstract
The hippocampus is associated with adaptive learning and memory, processing multimodal signals within its
intrinsic circuits, where inhibitory neurons have a fundamental role. Studies of inhibitory hippocampal neurons in
rodents have produced massive data on their types, physiology, and connectivity, organized into large
databases, but…
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