grant
Prevention of Necrotizing Enterocolitis
Organization UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTRLocation OKLAHOMA CITY, UNITED STATESPosted 1 Apr 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20250-4 weeks old1-Phosphatidylinositol 3-Kinase21+ years old3-Phosphoinositide Dependent Protein Kinase-1AKTAccelerationAdultAdult HumanAffectAkt proteinAttenuatedAutoregulationBacterial InfectionsBacterial TranslocationBody TissuesBreast MilkBreastmilkCell Communication and SignalingCell CountCell NumberCell SignalingCessation of lifeColitisColostrumComplexDataDeathDevelopmentDiphenylthiocarbazoneDiseaseDisorderDithizonDithizoneEmergenciesEmergency SituationEnteralEntericEnterocytesEpithelial CellsEpitheliumFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2FamilyGI Stem cellGlycosaminoglycansGoalsGoblet CellsGut Epithelial PermeabilityGut HyperpermeabilityGut permeabilityHamartinHomeostasisHumanHuman MilkHuman Mother's MilkHyaluronanHypoxiaHypoxicImmunoblottingImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImpairmentInfantInflammationInjuryInterventionIntestinalIntestinal Epithelial PermeabilityIntestinal HyperpermeabilityIntestinal permeabilityIntestinesIntracellular Communication and SignalingInvadedKO miceKinasesKlebsiella InfectionsKnock-out MiceKnockout MiceLactationLarge IntestineLiteratureMOF syndromeMammary Gland MilkMeasuresMechanistic Target of RapamycinMediatingMiceMice MammalsModelingModern ManMother's MilkMucopolysaccharidesMucosaMucosal TissueMucous MembraneMultiple Organ Dysfunction SyndromeMultiple Organ FailureMurineMusNatural regenerationNecrosisNecroticNecrotizing EnterocolitisNewborn InfantNewbornsNull MouseOccluding JunctionsOralOral AdministrationOral Drug AdministrationOxygen DeficiencyPI-3 KinasePI3-KinasePI3CGPI3KGammaPI3kPIK3PIK3CGPIK3CG genePKB KinasePaneth CellsPathogenesisPathologyPathway interactionsPhosphatidylinositol 3-KinasePhosphatidylinositol-3-OH KinasePhosphoinositide 3-HydroxykinasePhosphotransferase GenePhosphotransferasesPhysiological HomeostasisPlayPremature InfantPreventative strategyPreventative therapyPreventionPrevention strategyPreventive strategyPreventive therapyProliferatingProtein Kinase BProtein-Serine KinaseProtein-Serine-Threonine KinasesProtein-Threonine KinaseProteinsProto-Oncogene Proteins c-aktPtdIns 3-KinaseRAC-PK proteinRAFT1RNA SeqRNA sequencingRNAseqRadiation InjuriesRapamuneRapamycinRegenerationRegenerative capacityRiskRoleScientistSerine KinaseSerine-Threonine KinasesSerine/Threonine Protein Kinase GeneSeveritiesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSirolimusSmall IntestinesTSC1TSC1 geneTestingTherapeuticThreonine KinaseTight JunctionsTissuesTransphosphorylasesType I Phosphatidylinositol KinaseType III Phosphoinositide 3-KinaseWestern BlottingWestern ImmunoblottingWound RepairZonula Occludensadulthoodattenuateattenuatesbacteria infectionbacterial diseasebiological signal transductionbowelbowel inflammationc-akt proteinconditional knock-outconditional knockoutdevelopmentaldiet supplementdietary supplementsdysbacteriosisdysbiosisdysbioticepithelial injuryepithelial repairepithelium regenerationfeedinggastrointestinalgastrointestinal homeostasisgastrointestinal stem cellgenetic approachgenetic strategygut inflammationgut progenitorgut stem cellhPDK1infants born prematureinfants born prematurelyinflamed bowelinflamed gutinflamed intestineinjuredinjuriesinjury to the intestinesinsightintestinal barrierintestinal epitheliumintestinal homeostasisintestinal inflammationintestinal injuryintestinal maturationintestinal mucosal barrierintestinal progenitorintestinal stem cellsintraoral drug deliveryirradiation injurykinase inhibitorlactatinglactationallarge bowelmTORmammalian target of rapamycinmaternal milkmembermicrobial imbalancemortalitymouse modelmultiorgan failuremultiple organ system failuremurine modelnew approachesnewborn childnewborn childrennovelnovel approachesnovel strategiesnovel strategynutritional supplementpathwaypharmacologicpostnatalprematurepremature babypremature infant humanprematuritypreterm babypreterm infantpreterm infant humanpreventpreventingprotective effectprotein blottingprotein kinase B kinaseproto-oncogene protein RACproto-oncogene protein aktpuprac protein kinaseregenerateregenerate epitheliumregeneration abilityregeneration capacityrelated to A and C-proteinsmall bowelsocial rolesystemic inflammationsystemic inflammatory responsetranscriptome sequencingtranscriptomic sequencingtuberous sclerosis 1wound healingwound recoverywound resolution
Description preview
Project Summary/Abstract
Necrotizing enterocolitis (NEC) is the most devastating gastrointestinal pathology in the newborn period.
Although the pathogenesis is unclear, evidence suggests prematurity and formula feeding play major roles in
NEC. Our long-term goal is to identify strategies that promote postnatal maturation and barrier function in…
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