grant
Preventing and Understanding CHIP Evolution into AML: The role of the LY75 in the development of DNMT3A-mutant CH and associated myeloid neoplasms
Organization UKRILocation United Kingdom
UKRIUK ResearchGrantActive
Description preview
Myeloid neoplasms (MN) affect ~10 per 100,000 individuals per year and remain lethal to the majority. Most cases of MN arise from the clonal expansion of an HSC and its progeny driven by MN-associated somatic mutations; a condition known as Clonal Hematopoiesis (CH) and develop many decades after the initial mutational event. DNMT3A is one of the…
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