grant
Preventing and Reversing Interstitial Fibrosis in HFpEF
Organization VA WESTERN NEW YORK HEALTHCARE SYSTEMLocation BUFFALO, UNITED STATESPosted 1 Jan 2016Deadline 30 Jun 2028
VANIHUS FederalResearch GrantFY2025AddressAgingAllogenicAnimal Disease ModelsAnimal ModelAnimal Models and Related StudiesApoptosisApoptosis PathwayArteriesAttenuatedCOPDCardiacCardiac Failure CongestiveCardiovascular DiseasesCaringCause of DeathCell BodyCell TherapyCellsCessation of lifeChronicChronic Obstruction Pulmonary DiseaseChronic Obstructive Lung DiseaseChronic Obstructive Pulmonary DiseaseClinicalCongestive Heart FailureCoronaryDeathDevelopmentDevicesDiabetes MellitusDiastolic heart failureDiureticsDrugsDysfunctionEFRACEjection FractionFamily suidaeFibrosisFibrosis in the heartFibrosis in the myocardiumFibrosis within the heartFibrosis within the myocardiumFibrotic myocardiumFunctional disorderFundingHF with preserved ejection fractionHFpEFHeart DecompensationHeart failureHospital AdmissionHospitalizationHumanHypertensionHypertrophyImpairmentIncidenceInduction of ApoptosisInflammationInflammatoryInflammatory ResponseInjuryInterventionIschemic HeartIschemic Heart DiseaseIschemic myocardiumL-ProlineLV remodelingLeftLeft VentriclesLeft Ventricular HypertrophyLeft Ventricular RemodelingLeft ventricular structureMacrophageMedicationMicellesMicrovascular DysfunctionModelingModern ManMuscle CellsMyocardialMyocardial IschemiaMyocytesMφObesityPatientsPeptidesPharmaceutical PreparationsPhenotypePhysiopathologyPigsPre-Clinical ModelPreclinical ModelsPrevalenceProgrammed Cell DeathProliferatingProlineRegulationResearchRestRisk FactorsRodent ModelStretchingSuidaeSwineSymptomsTestingTnITranslatingTroponin IVascular Hypertensive DiseaseVascular Hypertensive DisorderVentricularVeteransWorkadiposityattenuateattenuatescardiac agingcardiac failurecardiac fibrosiscardiac ischemiacardiovascular disordercell based interventioncell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapychronic heart failurechronic obstructive pulmonary disorderco-morbidco-morbiditycomorbiditycoronary fibrosiscoronary ischemiacorpulencedevelopmentaldiabetesdisabilitydrug/agentfibrotic heartheart agingheart failure with preserved ejection fractionheart failure with preserved systolic functionheart fibrosisheart ischemiahigh blood pressurehyperpiesiahyperpiesishypertensive cardiomyopathyhypertensive diseasehypertensive disorderhypertensive heart diseasehypertensive heart disorderimprovedinhibitorinhibitory troponin Iinjuriesinterstitialleft ventricle remodelingmicrovascular complicationsmicrovascular diseasemilitary veteranmodel of animalmyocardial fibrosismyocardial ischemia/hypoxiamyocardium ischemianovelpathophysiologyporcinepreservationpreserved ejection fraction heart failurepressurepreventpreventingrecruitresponsesmall vessel diseasesuidsystolic hypertensionveteran population
Description preview
Heart failure with a preserved ejection fraction (HFpEF) is an increasingly prevalent problem and particularly so
amongst an aging Veterans population. It accounts for over half of all patients with heart failure. While there
have been considerable advances in understanding the mechanisms and treatment of patients with heart
failure when ejection…
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