grant
PrEP and MOUD Rapid Access for Persons who Inject Drugs: the CHORUS+ Study
Organization BOSTON MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 1 Sept 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AIDS VirusAIDS preventionAIDS testAIDS/HIV testAccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdanonAddressAdherenceAdoptedAdoptionAffectAlthoseApplication ContextAutomobile DrivingBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioralBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBiometricsBiometryBiostatisticsBloodBlood Reticuloendothelial SystemBostonBuprenorphineCaringCell PhoneCellular PhoneCellular TelephoneClinicClinical Laboratory Improvement AmendmentsCommunicable DiseasesCommunitiesConditioning TherapyControl GroupsCountyDataDiphosphatesDolophineDoseDrug userDrugsDrynessEffectivenessEnrollmentEpidemicEvaluationEvidence based interventionFoundationsFutureGoalsGroups at riskHIVHIV PreventionHIV riskHIV testHIV-1 testHIV-2 testHIV/AIDS preventionHomeHumanHuman Immunodeficiency VirusesHuman immunodeficiency virus testIndividualInfectionInfectious DiseasesInfectious DisorderInjecting drug userInjection Drug UserInterventionLAV-HTLV-IIILaboratoriesLymphadenopathy-Associated VirusMeasuresMedicalMedical centerMedicationMethadoneMethadoseMethodsMissionMobile PhonesModelingModern ManNIDANational Institute of Drug AbuseNational Institute on Drug AbuseNational Institutes of HealthOpiatesOpioidOutcomeOverdosePWIDPWUDParticipantPatientsPeople at riskPersonal awarenessPersonsPersons at riskPharmaceutical PreparationsPharmaciesPharmacy facilityPhasePhlebotomyPilot ProjectsPopulationPopulations at RiskPrEPPreventative strategyPrevention strategyPreventive strategyPrivacyPublic HealthPyrophosphatesQualitative MethodsQualitative ResearchRandomizedRandomized, Controlled TrialsRecommendationRecordsRecoveryResearchResearch MethodologyResearch MethodsSelf EfficacySelf PerceptionSelf imageSelf viewSiteSocial BehaviorSpottingsSubstance Use DisorderTenofovirTestingTrainingTreatment EfficacyUnited States National Institutes of HealthVenous blood samplingVireadVirus-HIVWalkingacceptability and feasibilityaddictionaddictive disorderarmbehavior interventionbehavioral interventioncare as usualcare fragmentationcocaine usecontextual factorsdetermine efficacydevelop therapydrivingdrug/agentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationenrollevaluate efficacyevidence baseexamine efficacyexperimentexperimental researchexperimental studyexperimentsheroin intakeheroin usehomeshypoimmunityiPhoneimmune deficiencyimmunodeficiencyimprovedimproved outcomeinformantinterestintervention developmentintervention efficacylong-term recoverymedication for opioid use disordermortalitymotivational enhancement therapymotivational interventionmotivational interviewmultidisciplinarynovelopiate crisisopiate overdoseopiate related overdoseopiate use disorderopioid crisisopioid drug overdoseopioid epidemicopioid induced overdoseopioid intoxicationopioid medication overdoseopioid overdoseopioid poisoningopioid related overdoseopioid toxicityopioid use disorderoutreachparticipant interviewpeerpeer coachingpeer instructionpeer led team learningpeer mentoringpeer recoverypeer teachingpeople who inject drugspeople who inject illicit drugspeople who use drugspeople who use illicit drugspersons who inject drugspersons who use drugspilot studypilot testpoint of carepre-exposure prophylaxispreventpreventingprimary outcomeprocess evaluationprogramsqualitative reasoningrandomisationrandomizationrandomized control trialrandomly assignedrapid assayrapid testrapid testingrapid testsrecruitresearch and methodsresponsescale upsecondary outcomeself awarenessself knowledgeself testingskillssmart phonesmartphonesocial stigmasociobehaviorsociobehavioralstigmasubstance usesubstance use and disordersubstance usingsyndemicsynergistic epidemictheoriestherapeutic efficacytherapy developmenttherapy efficacytreatment as usualtreatment developmenttrial designuptakeusual care
Description preview
PROJECT SUMMARY / ABSTRACT
The US opioid overdose epidemic has been accompanied by an increase in human immunodeficiency (HIV)
among persons who inject drugs. The co-occurrence of HIV and opioid use disorder (OUD) suggests that a
comprehensive approach to OUD and its infectious complications has the potential to improve outcomes. HIV
pre-exposure…
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