grant
Prefrontal impairment with stress- NE receptor subtype mechanisms.
NIHUS FederalResearch GrantFY20253'5'-cyclic ester of AMPADRB1ADRB1 geneADRB1RAcuteAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine, cyclic 3',5'-(hydrogen phosphate)AffinityAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnimalsAstrocytesAstrocytusAstrogliaAutomobile DrivingB1ARBETA1ARBrainBrain Nervous SystemCardiacCatecholaminesCell BodyCellsChronic stressCognitionCognitiveCognitive deficitsConfocal MicroscopyConnector NeuronCoupledCyclic AMPDataDendritic SpinesDiseaseDisorderDissectionDoseDrug IontophoresisEmotionalEncephalonExposure toFamilyFurazosinGoalsHeartHortega cellHumanHypotensivesImmediate MemoryImmuno-Electron MicroscopyImmunoelectron MicroscopyImmunofluorescenceImmunofluorescence ImmunologicImpairmentIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracellular Second MessengerIontophoresisK channelLabelLengthLevarterenolLevonorepinephrineLocationM mulattaM. mulattaMacaca mulattaMacaca rhesusMediatingMemory DeficitMemory impairmentMental disordersMental health disordersMicrogliaModern ManMolecularMonkeysMyocardiumNerve CellsNerve UnitNeural CellNeurocyteNeuronsNightmareNoradrenalineNorepinephrineNorepinephrine ReceptorsPTSDPatientsPerformancePhysiologicPhysiologicalPost-Traumatic NeurosesPost-Traumatic Stress DisordersPosttraumatic NeurosesPotassium ChannelPotassium Ion ChannelsPrazosinPrefrontal CortexPrimatesPrimates MammalsPropanololPropranololPsychiatric DiseasePsychiatric DisorderPyramidal CellsReceptor ProteinResearchRhesus MacaqueRhesus MonkeyRiskRisk FactorsRoleSchizophreniaSchizophrenic DisordersSecond Messenger SystemsSecond MessengersSensoryShort-Term MemorySiteStressSympathinsTechniquesTestingTherapeuticWorkacute stressadenosine 3'5' monophosphateamygdaloid nuclear complexantagonismantagonistastrocytic gliabiological adaptation to stresscAMPcardiac musclecell typecognitive defectsdementia praecoxdendrite spinedesigndesigningdrivingeffective therapyeffective treatmentfightinggain of function mutationgitter cellheart muscleiontophoresis therapymemory dysfunctionmental illnessmental representationmesogliamicroglial cellmicrogliocyteneuronalperivascular glial cellpost-trauma stress disorderposttrauma stress disorderpresynapticpsychiatric illnesspsychological disorderreaction; crisisreceptorresponseschizophrenicsedativeside effectsignal transduction second messengerssocial rolestress reductionstress responsestress; reactionstressortraumatic neurosistreatment strategyvoltageworking memory
Description preview
Abstract- The dorsolateral prefrontal cortex (dlPFC) mediates working memory and top-down control, but is
impaired by acute or chronic stress, and is dysfunctional in most mental disorders. Stress exposure increases
norepinephrine (NE) release, which strengthens amygdala emotional responses via (β-AR and α1-AR, but
weakens the dlPFC via α1-AR,…
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