grant
Predicting the hemodynamic response to mitral valve interventions with pressure-volume analysis
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 20 Jul 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025Active Follow-upActive LearningAcuteAddressAdrenergic AgentsAdrenergic DrugsAdrenergicsAgeAmerican Heart AssociationAreaArea Under CurveAwardBicuspid ValveBlood PressureCardiacCardiac ChronotropismCardiac OutputCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCaringCathetersClinicalConventional SurgeryCooperative LearningDataDevelopmentDiagnosisDiagnosticDrug TherapyEFRACEchocardiogramEchocardiographyEjection FractionEventExperiential LearningFoundationsGuidelinesHealth StatusHeart RateHeart Valve DiseasesHeart VascularHeart failureHeterogeneityHospital AdmissionHospitalizationImageIndividualIndustryInternationalInterventionIntraventricular PressureInvestigatorsKnowledgeLVEFLeftLeft Ventricular DysfunctionLeft Ventricular Ejection FractionLeft Ventricular FunctionLevel of HealthLinkMeasurementMeasuresMedicalMentorsMentorshipMethodsMissionMitral IncompetenceMitral InsufficiencyMitral RegurgitationMitral ValveMitral Valve IncompetenceMitral Valve InsufficiencyMitral Valve RegurgitationMorbidityMorbidity - disease rateMyocardialNHLBINational Heart, Lung, and Blood InstituteOutcomeParticipantPatient Outcomes AssessmentsPatient Reported MeasuresPatient Reported OutcomesPatient SelectionPatientsPharmacological TreatmentPharmacotherapyPhysiologicPhysiologic intraventricular pressurePhysiologicalPopulationPrevalenceProceduresProtocolProtocols documentationPublic HealthR-Series Research ProjectsR01 MechanismR01 ProgramRandomizedResearchResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearchersRisk AssessmentStructureSurgical ValvesTechniquesTimeTrainingTransthoracic EchocardiographyValvular Heart DiseasesValvular Heart DisorderVentricularVentricular FunctionVentricular PressureWorkactive followupagesanalyzing longitudinalbiomedical implantcardiac failurecardiac valve diseasecardiac valve disordercardiac valvular diseasecardiovascular imagingcareercirculatory systemclinical practicecostdeep learningdeep learning methoddeep learning strategydegenerative valvular heart diseasedevelopmentaldrug interventiondrug treatmentexperiencefollow upfollow-upfollowed upfollowuphealth levelheart outputheart sonographyheart valve disorderhemodynamicsimagingimplant deviceimplantable deviceimplantationimprovedindexingindwelling deviceinsightinterestleft ventricle abnormalitylongitudinal analysislung artery blood pressuremeetingmeetingsminimally invasivemortalitynovelpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspre-clinical studypreclinical studypressurepressure in pulmonary arteriespressure sensorpreventpreventingprospectivepulmonary arterial blood pressurepulmonary arterial pressurepulmonary artery pressurepulmonary artery systolic pressurerandomisationrandomizationrandomly assignedrepairrepairedresponseresponse to therapyresponse to treatmentskillsstandard of carestudy populationtherapeutic responsetherapy responsetreatment responsetreatment responsivenesstrial designwirelesswireless implant
Description preview
Project Summary: The proposed K23 development award will enable Dr. Michael Brener to become an
independent investigator in the field of valvular heart disease (VHD). Dr Brener is an interventional cardiologist
and plans to use this training to conduct research where invasive hemodynamics are acquired to better
diagnose and manage individuals with…
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