grant
Preconditioning brain white matter against ischemia
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 15 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAKTAKT Signaling PathwayAdenosine Cyclic Monophosphate-Dependent Protein KinasesAgeAgingAkt proteinApoplexyArterial ObstructionArterial OcclusionArtery ObstructionAttenuatedAxonBehavior assessmentBehavioralBioinformaticsBlood PlasmaBrainBrain Hypoxia-IschemiaBrain Nervous SystemBrain Vascular AccidentCDK5CDK5 geneCancer PatientCaringCasein Kinase TSCasein Kinase-2Caucasian FemalesCaucasian WomenCause of DeathCell Communication and SignalingCell Division Kinase 5 GeneCell SignalingCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeClinicalClinical ResearchClinical StudyCommon carotid arteryCorrelation StudiesCyclic AMP-Dependent Protein KinasesDataDysfunctionElectron MicroscopyElectrophysiologyElectrophysiology (science)EncephalonEventFDA approvedFDA licensed drugsFDA-approved agentsFDA-approved drugFDA-approved medicationsFDA-approved pharmaceuticalsFDA-approved therapeutic agentFemaleFood and Drug Administration approved drugFood and Drug Administration approved medicationsFood and Drug Administration approved pharmaceuticalsFunctional disorderFundingGTP PhosphohydrolasesGTPasesGeneralized GrowthGenus HippocampusGoalsGrowthGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesHumanImageIn VitroIntracellular Communication and SignalingIschemiaIschemic PreconditioningMediatingMiceMice MammalsMicroRNAsMitochondriaMitochondrial ProteinsModelingModern ManMotilityMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeurological disabilityNeuronsNeurophysiology / ElectrophysiologyOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellPKAPathway interactionsPatientsPhysiopathologyPlasmaPlasma SerumProtein Kinase AProtein Kinase BProtein Kinase CK2Protein Kinase CKIIProto-Oncogene Proteins c-aktRAC-PK proteinRecovery of FunctionRecurrenceRecurrentRegulationReportingReticuloendothelial System, Serum, PlasmaRiskRodentRodentiaRodents MammalsRoleSamplingSeahorseSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeStatistical CorrelationStrokeStructureSurvivorsTestingTherapeuticTissue GrowthTranslatingUpregulationValidationWhite FemalesWhite Womenaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsagesaging populationartery occlusionattenuateattenuatesaxon damageaxon injuryaxonal damageaxonal injurybehavior outcomebehavioral assessmentbehavioral outcomebiological signal transductionbrain attackc-akt proteincAMP-Dependent Protein Kinasescasein kinase IIcerebral vascular accidentcerebrovascular accidentclinical applicabilityclinical applicationclinical relevanceclinically relevantdisabilityelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsfunctional recoverygray matterguanosinetriphosphatasehealth care burdenhealth care economicshigh riskhypoxia/ischemiaimagingimprovedin vivoin vivo Modelinhibitorischemia injuryischemic injurymalemiRNAmitochondrialneuronalnovelontogenypathophysiologypathwaypharmacologicpopulation agingpreconditioningpreservationprotective effectproto-oncogene protein RACproto-oncogene protein aktrac protein kinaserelated to A and C-proteinsexsocial rolespatial and temporalspatial temporalspatiotemporalstroke eventstroke patientstroke survivorstrokedstrokessubcortical ischemiasubcortical ischemic vascular diseasesubstantia albasubstantia griseatherapeutic targetthree dimensionaltraffickingvalidationswhite matterwhite matter injury♀♂
Description preview
PROJECT SUMMARY
A growth in the aging population together with improved stroke care has resulted in an increase in survivors and
a rise in recurrent ischemic events, presenting major challenges for overburdened healthcare economics for
these patients. Consequently, approaches to induce tolerance in the brain against ischemia have gained new…
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