grant
Preconception Maternal Nutrition, Offspring DNA Methylation, and InfantGrowth in Low Resource Settings
Organization UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTRLocation OKLAHOMA CITY, UNITED STATESPosted 15 Jan 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY20260-11 years old21+ years old3-arm study5 year old5 years of ageAddressAdultAdult HumanAdult-Onset Diabetes MellitusAgeAnthropometryBMIBMI percentileBMI z-scoreBelgian CongoBindingBirthBirth lengthBody mass indexCancersCardiovascular DiseasesCell BodyCellsCells Placenta-TissueChildChild HealthChild YouthChildren (0-21)Chronic DiseaseChronic IllnessChronologic Fetal MaturityChronologyConceptionsConsumptionCytosineDNA MethylationDataDemocratic Republic of the CongoDietary InterventionDinucleoside PhosphatesDiseaseDisorderEducational AchievementEducational StatusEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpigenetic ageEthnic OriginEthnicityFemaleFetal AgeGene TranscriptionGeneralized GrowthGenetic TranscriptionGenomic SegmentGestationGestational AgeGoalsGrimAge clockGrowthGrowth and DevelopmentGrowth and Development functionGuanidinesGuatemalaHannum clockHealthHealth BenefitHorvath clockHumanIndiaIndividualInfantKetosis-Resistant Diabetes MellitusLMICLifeLinkLipidsLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingMalignant NeoplasmsMalignant TumorMalnutritionMaternal NutritionMaternal dietMaturity-Onset Diabetes MellitusMethylationMicronutrientsModern ManMolecularMolecular InteractionMorbidityMothersNIDDMNeonatalNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNormal PlacentomaNutrientNutritionNutrition InterventionsNutritional DeficiencyNutritional InterventionsNutritional statusObesityPakistanParturitionPhenoAge clocksPhenotypePlacentaPlacenta Embryonic TissuePlacentomePregnancyQuetelet indexRNA ExpressionRandomized, Controlled TrialsReportingResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingRiskSlow-Onset Diabetes MellitusStable Diabetes MellitusT2 DMT2DT2DMTestingTissue GrowthTranscriptionType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUndernutritionVulnerable PopulationsWomanZaireaccelerated agingaccelerated biological ageaccelerated biological agingaccelerated epigenetic ageaccelerated epigenetic agingaccelerated pace of epigenetic agingacceleration in epigenetic ageadiposityadult onset diabetesadulthoodage 5age 5 yearsage accelerationagesarmbefore conceptioncardiovascular disorderchronic disordercorpulencediet interventiondietary deficiencydinucleotideearly-life nutritioneducational levelepigenetic age clocksepigenetic biomarkerepigenetic clockepigenetic markerepigenetic molecular clocksepigeneticallyepigenomefaster epigenetic agingfaster rates of epigenetic agingfetalfive year oldfive years of agegenome segmentgenomic regionglobal healthhealthspanhealthy life spanhuman capitalimprovedincreased epigenetic ageincreased epigenetic agingincreased rates of epigenetic agingintervention armketosis resistant diabeteskidslow and middle-income countrieslow income countrymalemalignancymalnourishedmaternal nutrition during pregnancymaturity onset diabetesmethyl groupmethylation biomarkermethylation clockmethylation markermortalitymother nutritionneoplasm/cancernovelnutrition deficiencynutrition deficiency disordernutritional deficiency disorderoffspringontogenypostnatalpreconceptionprepregnancyprior to conceptionrandomized control trialrapid epigenetic agingresponserural arearural locationrural regionsexthree-arm studytraining achievementtraining leveltraining statustreatment armtype 2 DMtype II DMtype two diabetesvulnerable groupvulnerable individualvulnerable peopleyoungster♀♂
Description preview
PROJECT ABSTRACT
Growth stunting is a global health problem that impacts ~149 million children under 5 years of age living
primarily in low-and-middle income-countries, particularly low-income countries. Mothers and infants are
particularly vulnerable to the impacts of malnutrition, including inadequacy of micronutrients which contributes to…
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