grant
Preclinical medication development for stimulant use disorder
Organization NATIONAL INSTITUTE ON DRUG ABUSELocation UNITED STATES
NIHUS FederalResearch GrantFY20255-HT5-HT(1A) Receptor5-HT(2A) Receptor5-HT-2A Gene5-HT1A Receptor5-HT2A5-HT2A Receptor5-Hydroxytryptamine5-Hydroxytryptamine (Serotonin) Receptor 2A Gene5-Hydroxytryptamine 1A Receptor5-Hydroxytryptamine Receptor 2A5-Hydroxytryptamine Receptor 2A Gene5HT5HT transporter5HTT proteinActiqAcuteAdvocateAgonistAnxietyArtificial HibernationAssayBindingBioassayBiological AssayBrainBrain Nervous SystemBuprenorphineCarrier ProteinsClinical ResearchClinical StudyCocaineCognitionCommon Rat StrainsCrystal MethCrystal methamphetamineDAT dopamine transporterDeoxyephedrineDesoxyephedrineDevelopmentDimethyltryptamineDopamineDoseDrug TherapyDrugsDuragesicEncephalonEnteramineEquilibriumFDA approvedFentanestFentanylFentylGeneHomologHTR2HTR2 GeneHTR2AHTR2A geneHallucinogenic AgentsHallucinogenic DrugsHallucinogenic SubstancesHallucinogensHeadHippophaineHomologHomologous GeneHomologueHybridsHydroxytyramineIllicit DrugsIn VitroIndolylethylaminesIngestionInvestigationJournalsLaboratoriesLigandsLocomotionLong-Term EffectsMagazineManuscriptsMediatingMedicationMedicineMental DepressionMethamphetamineMethodologyMethylamphetamineMiceMice MammalsModelingMolecular InteractionMurineMusN,N-DimethyltryptamineN,N-dimethyl-1H-indole-3-ethanamineN-MethylamphetamineNIDANational Institute of Drug AbuseNational Institute on Drug AbuseNeurobiologyPatientsPeer ReviewPerceptionPharmaceutical PreparationsPharmacological TreatmentPharmacologyPharmacotherapyPhentanylPreclinical dataPropertyPsilocibinPsilocybinPsychedelic AgentsPsychedelicsPsychotomimetic AgentsPublicationsPublishingRatRats MammalsRattusReceptor ActivationReceptor ProteinRecreational DrugsReportingResearchRodent ModelScientific PublicationSelf AdministeredSelf AdministrationSerotoninSerotonin 1A ReceptorSerotonin 2A ReceptorSerotonin 5-HT-2 Receptor GeneSerotonin 5-HT-2A ReceptorSerotonin Receptor 5-HT1ASerotonin Receptor 5-HT2ASeveritiesSiteStimulantStructure-Activity RelationshipSubcutaneous InjectionsSubstance Use DisorderTestingTherapeuticTherapeutic EffectTransport Protein GeneTransport ProteinsTransporter ProteinTryptaminesUnited StatesWorkabuse liabilityabuse potentialabused drugabused drugsaddiction to psychostimulantsaddiction to stimulantsanalogantagonismantagonistbalancebalance functionchemical structure functioncigarette smokingcigarette usedepressiondevelopmentaldopamine transporterdrug abuseddrug actiondrug developmentdrug interventiondrug of abusedrug seeking behaviordrug treatmentdrug/agentdrugs abuseddrugs of abuseextracellularheroin intakeheroin usein vivoinduced hypothermiaingestmedication administrationmethmonoamineneurobiologicalnicotine gumnon-medical usenonmedical usenoveloverdose deathoverdose fatalitiespharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspre-clinicalpre-clinical developmentpreclinicalpreclinical developmentpreclinical findingspreclinical informationpsychedelic drugpsychostimulant addictionpsychostimulant dependencepsychostimulant usepsychostimulant use disorderpsychotomimetic drugreceptorresponseserotonin transportersodium-dependent serotonin transporterstimulant addictionstimulant dependencestimulant usestimulant use disorderstructure function relationshipsubdermal injectionsubstance use and disordersynthetic opiatesynthetic opioiduse of stimulants
Description preview
Significant progress was made on this project, which involves the preclinical development of candidate medications for stimulant use disorders. Four relevant manuscripts were published in peer-reviewed journals over the last year. Two articles characterize the pharmacology of novel 5-HT2A receptor agonists in mice, whereas two other articles…
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