grant
Preclinical analyses of advanced prostate cancer in genetically-engineered mice
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 6 Aug 2013Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025AccelerationAllograftingAndrogenic AgentsAndrogenic CompoundsAndrogensAnti-OncogenesAnti-androgen TherapyAnti-androgen TreatmentAntioncogenesAssayBRCA1BRCA1 Gene ProductBRCA1 ProteinBRCA1 geneBRCA2BRCA2 geneBioassayBiochemicalBiologicalBiological AssayBiological FunctionBiological ProcessBreast Cancer 1 GeneBreast Cancer 1 Gene ProductBreast Cancer 2 GeneBreast Cancer Type 1 Susceptibility GeneBreast Cancer Type 1 Susceptibility ProteinBreast Cancer Type 2 Susceptibility GeneBreast-Ovarian Cancer ProteinCancer CauseCancer EtiologyCancer Suppressor GenesCancer TreatmentCastrationCell BodyCellsCessation of lifeClinical TrialsComplementComplement ProteinsComputational toolkitDNA DamageDNA Damage RepairDNA InjuryDNA RepairDNA Repair GeneDNA analysisDNA repair proteinDeathDevelopmentDiseaseDisease ProgressionDisorderDouble Strand Break RepairDrug CombinationsDrug TargetingDrugsEarly Onset Gene Breast Cancer 1Early Onset Gene Breast Cancer 2Early Onset Protein Breast Cancer 1EmerogenesFANCD1FoundationsFundingFutureGEM modelGEMM modelGenerationsGenesGenetically Engineered MouseHereditary Breast Cancer 1Hereditary Breast Cancer 2HumanIndividualMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant neoplasm of prostateMalignant prostatic tumorMedicationMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Prostate CancerMetastatic TumorMiceMice MammalsModelingModern ManMolecularMurineMusNeoplasm MetastasisOnco-Suppressor GenesOncogenes-Tumor SuppressorsOrganoidsPatientsPharmaceutical PreparationsPhenotypePlayPrimary NeoplasmPrimary TumorProstateProstate CAProstate CancerProstate Carcinoma MetastaticProstate GlandProstate NeoplasmsProstate TumorProstate malignancyProstatic GlandProstatic NeoplasiaProstatic NeoplasmsRNF53Recessive OncogenesResearch ResourcesResistanceResourcesRoleSecondary NeoplasmSecondary TumorSeriesSingle-Nucleus SequencingSurgical CastrationTherapeutic AndrogenTreatment FailureTumor Suppressing GenesTumor Suppressor GenesUnscheduled DNA SynthesisVariantVariationadvanced prostate canceranalyze DNAanti-cancer therapybiologicbonebrca 1 genebrca 2 genecancer metastasiscancer therapycancer-directed therapycandidate identificationchemotherapyclinical investigationclinical practiceclinical relevanceclinically relevantcomplementationcomputational toolboxcomputational toolscomputational toolsetcomputerized toolsdeprivationdevelopmentaldisease riskdisorder riskdrug/agentgene functiongenetically engineered mouse modelgenetically engineered murine modelgenome integritygenome scalegenome-widegenomewidegenomic integrityindividual patientindividualized cancer careindividualized oncologyinnovateinnovationinnovativeinsightloss of functionmennew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoncosuppressor genepersonalized oncologypre-clinicalprecision cancer careprecision cancer medicineprecision oncologypreclinicalprostate cancer progressionprostate carcinogenesisprostate tumorigenesisrepair functionreparative functionresistantresponseresponse to therapyresponse to treatmentsNuc-Seqsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial roletargeted agenttherapeutic responsetherapy failuretherapy responsetreatment responsetreatment responsivenesstumortumor cell metastasis
Description preview
Project Summary/Abstract
Advanced prostate cancer represents a major cause of cancer death in men, usually as a consequence
of treatment failure, which gives rise to aggressive disease variants that are highly metastatic. Among the major
biological processes that are causally dysregulated in advanced prostate cancer are those related to DNA…
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