grant
Precision brain charts for imaging-genomics of schizophrenia and the psychosis spectrum
Organization CHILDREN'S HOSP OF PHILADELPHIALocation PHILADELPHIA, UNITED STATESPosted 1 Jul 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202512-20 years old21+ years oldAccelerationActive Follow-upAdolescenceAdultAdult HumanAgeAnatomic SitesAnatomic structuresAnatomyAreaBenchmarkingBest Practice AnalysisBrainBrain Nervous SystemBrain imagingBrain regionBrain scanCase-Base StudiesCase-Comparison StudiesCase-Compeer StudiesCase-Referent StudiesCase-Referrent StudiesCase/Control StudiesCell Communication and SignalingCell SignalingClinicalClinical EvaluationClinical TestingCommunitiesDataData SetDevelopmentDevelopmental GeneDiagnosisDiseaseDisorderEarly identificationEncephalonEvolutionFollow-Up StudiesFollowup StudiesFoundationsFutureGWA studyGWASGene variantGeneralized GrowthGeneticGenetic studyGenomeGenomicsGenotypeGoalsGrowthHeightHeritabilityImageIndividualIndividual DifferencesIntracellular Communication and SignalingInvestigationInvestigatorsLinkMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMapsMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceModelingNMR ImagingNMR TomographyNatureNeural DevelopmentNeuranatomiesNeuranatomyNeuroanatomiesNeuroanatomyNeurobiologyNoiseNuclear Magnetic Resonance ImagingParticipantPatternPediatric ResearchPediatricsPennsylvaniaPhenotypePhiladelphiaPsychiatryPsychosesPublishingQuality ControlReference StandardsReportingReproducibilityResearchResearch PersonnelResearch ResourcesResearchersResolutionResourcesRiskRisk-associated variantSample SizeSamplingScanningSchizophreniaSchizophrenic DisordersScientistSensoryShapesSideSignal TransductionSignal Transduction SystemsSignalingSiteSurfaceSymptomsSynapsesSynapticTechniquesTestingThickThicknessTissue GrowthTwin Multiple BirthTwinsUniversitiesWeightWorkYouthYouth 10-21Zeugmatographyactive followupadolescence (12-20)adulthoodage associated effectsage effectage related effectsagesaging effectallelic variantanalyzing longitudinalassociation cortexassociation corticalassociation corticesbenchmarkbiobankbiological signal transductionbiorepositorybrain morphologybrain visualizationcase controlcase-controlledcase-controlled studieschild health careclinical testcohortdementia praecoxdevelopmentalfollow upfollow-upfollowed upfollowupfunctional genomicsgenetic variantgenome wide analysisgenome wide associationgenome wide association scangenome wide association studygenome wide studiesgenome-wide analysisgenome-wide identificationgenomewide association scangenomewide association studygenomic variantglobal gene expressionglobal transcription profilegray matterheritability patternhigh risk grouphigh risk individualhigh risk peoplehigh risk populationimage processingimagingimaging geneticsimaging studyimpact of ageinfluence of ageinnovateinnovationinnovativeinternet resourcelife spanlifespanlongitudinal analysisneural imagingneuro-imagingneurobiologicalneurodevelopmentneuroimagingneuroinformaticsneurological imagingnovelon-line compendiumon-line resourceonline compendiumonline resourceontogenypediatric carepediatric health carepsychosis riskrate of changeresearch clinical testingresolutionsrisk allelerisk generisk genotyperisk locirisk locusrisk variantschizophrenicspectral imagespectral imageryspectrographspectrum imagespectrum imagerysubstantia griseasynapsetherapeutic stratificationtranscriptometranslational studytreatment stratificationtrendweb resourceweb-based resourceweightswhole genome association analysiswhole genome association studyyouth age
Description preview
ABSTRACT
An unmet need for psychiatric neuroimaging is a standard developmental frame of reference to benchmark
studies of neurodevelopmental conditions such as schizophrenia the psychosis spectrum (PS). Using a
modelling approach that has proven successful for non-imaging growth charts in clinical pediatrics, and in our
preliminary work that was…
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