grant
Precise GI Drug Delivery and Modeling with Pharmacomicrobiomics
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025AffectAlimentary CanalAutoregulationBehaviorCellular Immune FunctionChronicClinical PharmacologyCoupledCouplingDigestive TractDiseaseDisorderDistalDrug DeliveryDrug Delivery SystemsDrug FormulationsDrug KineticsDrug ModelingsDrug ModulationDrug PrecursorsDrugsFormulationFutureGI TractGI microbiomeGastrointestinal AgentsGastrointestinal DrugsGastrointestinal TractGastrointestinal tract structureGoalsHealthHomeostasisImmuneImmunesIndividualIntermediary MetabolismInterventionKineticsL-TryptophanLevotryptophanMedicationMetabolicMetabolic ProcessesMetabolismOralPharmaceutical PreparationsPharmacokineticsPhysiologicPhysiologicalPhysiological HomeostasisPlayPro-DrugsProcessProdrugsProductionPropertyResearchRoleSafetyShort-Chain Fatty AcidsSystemTherapeuticTryptophanVariantVariationVolatile Fatty Acidsabsorptionalimentary tractalter microbiomedesigndesigningdigestive canaldigestive tract microbiomedrug developmentdrug metabolismdrug/agentdysbacteriosisdysbiosisdysbioticenteric microbiomegastrointestinalgastrointestinal microbiomegut healthgut microbiomegut-associated microbiomeimmune functionin vivo Modelinsightintestinal biomeintestinal microbiomemicrobialmicrobial imbalancemicrobiomemicrobiome adaptationmicrobiome alterationmicrobiome community compositionmicrobiome compositionmicrobiome perturbationmicrobiome species compositionmicrobiome structurenanonano formulationnanoformulationnovelpharmacokinetic modelprecision medicineprecision-based medicineprogramsresponseside effectsocial rolespatial and temporalspatial temporalspatiotemporaltargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttool
Description preview
Precise GI Drug Delivery and Modeling with Pharmacomicrobiomics
Project Summary/Abstract
The gut microbiome plays a critical role in modulating drug metabolism, efficacy, and safety, influencing how
therapeutic compounds are absorbed, distributed, and processed in the body. This is particularly important in
prodrug design, which seeks to achieve…
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