grant
PRE3BAD: Preclinical Research on Emerging Environmental Exposures, Brain Aging, and Dementia
Organization UNIVERSITY OF NEW MEXICO HEALTH SCIS CTRLocation ALBUQUERQUE, UNITED STATESPosted 30 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AD dementiaAD modelAD related dementiaADRDAccelerationAgeAge MonthsAgingAirAir PollutantsAir PollutionAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease modelAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimers DementiaAmentiaAmyloidosisAridityArizonaArteriosclerotic DementiaAutopsyBBB crossingBetulaBetula GenusBiochemicalBiologyBirchBlood - brain barrier anatomyBlood-Brain BarrierBrainBrain Nervous SystemCadmiumCancersCardiovascular DiseasesCd elementClimatologyCollaborationsCopperCountryCu elementDNADataDegenerative Neurologic DisordersDementiaDeoxyribonucleic AcidDietDisparateEncephalonEnvironmentEnvironmental ExposureEnvironmental PollutantsEnvironmental ToxinEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFoodGroups at riskHealthHeavy MetalsHemato-Encephalic BarrierHumanHuman FigureHuman bodyHydrogen OxideKI miceKnock-in MouseLeadLifeMalignant NeoplasmsMalignant TumorManganeseMedicineMeta-AnalysisMetalsMiningMn elementModern ManMolecularNatureNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologicNeurologic Degenerative ConditionsNeurologic outcomeNeurologicalNeurological outcomeNeuron DegenerationNew MexicoO3OralOutcomeOzonePM2.5Particulate MatterPathogenesisPathologicPathway interactionsPatternPb elementPeople at riskPersons at riskPhenotypePlasticsPopulationPopulations at RiskPredicting RiskPrimary Senile Degenerative DementiaProteinsProteomicsRegimenResearchResistanceSmokeSourceSwedenTauopathiesTexasToxic Environmental AgentsToxic Environmental SubstancesToxicant exposureTransition ElementsUncertaintyUniversitiesUniversity resourcesVascular DementiaWaterWildfireaged brainagesaging brainalzheimer modelalzheimer riskamyloid diseaseanthropogenesisanthropogenicarid conditionsarid environmentbehavior phenotypebehavioral healthbehavioral impairmentbehavioral phenotypingblood-brain barrier crossingbloodbrain barrierbloodbrain barrier crossingbrain healthcardiovascular disordercerebrovascular contributions to dementiaclimate changeclimatic changescohortdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdietsdoubtearly life exposureenvironmental contaminantenvironmental justiceenvironmental stressesenvironmental stressorenvironmental toxicantepigeneticallyextreme heatfine particlesfine particulate matterflow cytophotometryforecasting riskglobal climate changehazardheavy metal Pbheavy metal leadhigh dimensionalityhigh riskimpaired behaviorindigenous communityknockin micelate in lifelate lifelife spanlifespanlipidomicsmalignancymetabolic profilemetabolism measurementmetabolomemetabolomicsmetabonomemetabonomicsmouse modelmultiomicsmultiple omicsmurine modelnano plasticsnecropsyneoplasm/cancerneural degenerationneural inflammationneurodegenerationneurodegenerativeneurodegenerative illnessneuroinflammationneuroinflammatoryneurological degenerationneuronal degenerationneuropathologicneuropathologic tauneuropathologicalneuropathological tauneuropathologynovelpanomicspathwaypollutantpostmortempre-clinicalpre-clinical researchpreclinicalpreclinical researchpredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive riskpredicts riskprimary degenerative dementiaprogramsprotein homeostasisproteostasisresistantrespiratoryrisk predictionrisk predictionssenile dementia of the Alzheimer typetau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau proteinopathytau related neurodegenerationtau-induced pathologytauopathic neurodegenerative disordertauopathytoxic exposuretoxicanttranscriptomicstransition metalvascular contributions in dementiavascular contributions to dementiavascular related dementiawild firewildland firewood smokewoodsmoke
Description preview
Environmental stressors may promote and/or accelerate neurodegenerative diseases. The US population has
been progressively aging, resulting in prolonged duration of environmental toxicant exposures and a potential
for increased vulnerability to new environmental insults. Consequently, there is a growing population at risk for
Alzheimer’s disease…
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