grant
Pre-synaptic events in homologous recombination and maintenance of genomic stability
Organization SAINT LOUIS UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 28 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AbscissionAdaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAllelesAllelomorphsBRCA2BRCA2 Gene ProductBRCA2 ProteinBRCA2 geneBase PairingBindingBiological FunctionBiological ProcessBreast Cancer 2 GeneBreast Cancer 2 Gene ProductBreast Cancer PatientBreast Cancer Type 2 Susceptibility GeneBreast Cancer Type 2 Susceptibility ProteinBreast Tumor PatientCancersCell BodyCell ProtectionCellsChaperoneChromosomal RearrangementChromosomal SynapsisChromosome PairingChromosomesCodeCoding SystemComplexCytoprotectionDNADNA BindingDNA Binding InteractionDNA Double Strand BreakDNA Repair Protein XRCC2DNA boundDNA mutationDNA replication factor ADefectDeoxyribonucleic AcidDouble-Stranded DNAEarly Onset Gene Breast Cancer 2Early Onset Protein Breast Cancer 2Enzyme GeneEnzymesEventExcisionExtirpationFANCD1FRETFamilial Breast CarcinomaFilamentFluorescence Light MicroscopyFluorescence MicroscopyFluorescence Resonance Energy TransferFörster Resonance Energy TransferGeneHomologGeneralized GrowthGenesGenetic ChangeGenetic defectGenetic mutationGenomeGenome InstabilityGenome StabilityGenomic InstabilityGenomic StabilityGrowthHereditaryHereditary Breast CancerHereditary Breast Cancer 2Hereditary Breast CarcinomaHomologHomologous GeneHomologueHumanIndividualInheritedInvadedLeadLesionMaintenanceMalignant NeoplasmsMalignant TumorMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatorModelingModern ManMolecular ChaperonesMolecular InteractionMutationNucleoproteinsPathway interactionsPb elementPositionPositioning AttributePropertyProteinsRAD51 proteinRAD51CRAD51C geneRAD52RAD52 geneRad51 recombinaseRemovalResectedResolutionRoleSS DNA BPSingle-Stranded DNASingle-Stranded DNA-Binding ProteinSisterSister ChromatidSortingSpecificitySurgical RemovalSynapsisSystemTailTestingTissue GrowthVisualizationWorkX-Ray Repair Cross Complementing Protein 2XRCC2XRCC2 geneYeast homolog of RAD52Yeastsadapter proteinbrca 2 genecytoprotectiveds-DNAdsDNAexperimentexperimental researchexperimental studyexperimentsfamilial breast cancerfeature detectionfeature recognitiongenetic informationgenome integritygenome mutationgenomic integrityheavy metal Pbheavy metal leadhigh riskhomologous recombinationin vivoindividuals with breast cancermalignancymolecular imagingmolecule imagingmonomerneoplasm/cancerontogenyparalogparalogous genepathwaypatients with breast cancerperson with breast cancerpresynapticrecombinaserepairrepairedreplication factor Areplication protein Aresectionresolutionssingle moleculesingle-strand binding protein RP-Asocial rolessDNAtooltumor
Description preview
SUMMARY
Lesions, breaks, and errors in DNA are drivers of genomic instability. Double-stranded DNA breaks
(DSBs) are a particularly severe form of damage and are repaired by the homologous recombination (HR)
pathway. On average, ~10 to 50 DSBs occur per cell per day and thus pose the highest risk to genomic integrity.
Unrepaired DSBs lead to…
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