grant
Pre-clinical validation of 3D-printed nerve conduits for pediatric peripheral nerve repair
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 27 Jun 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20260-11 years old18 year old18 years of age3-D3-D print3-D printer3-Dimensional3D3D Print3D printer3D printingAutograftAutoimmune DiseasesAutologousAutologous TransplantationAutotransplantBiocompatible MaterialsBiological MimeticsBiomaterialsBiomimeticsBirthBody partBrachial PlexusBrachial plexus structureChildChild YouthChildhoodChildren (0-21)ClinicalCollectionCommercial gradeComputer-Aided DesignComputer-Assisted DesignDataDefectDevicesDiabetes MellitusDiagnosticDimensionsDistalElectrophysiologyElectrophysiology (science)EngineeringEvaluationFDA approvedGelatinGeneralized GrowthGenerationsGeometryGoalsGrowthHarvestHead and NeckHead and neck structureHumanImageImplantIn SituInfantInjuryLengthLoss of SensationLower ExtremityLower LimbMR ImagingMR TomographyMRIMRI ScansMRIsMagnetic Resonance ImagingMagnetic Resonance Imaging ScanMedicalMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMembrum inferiusMembrum superiusMethodsMiceMice MammalsModelingModern ManMonitorMorbidityMurineMusNMR ImagingNMR TomographyNerveNerve FibersNerve RegenerationNerve TissueNervous TissueNeuro-regenerationNeuromaNeurophysiology / ElectrophysiologyNeuroregenerationNuclear Magnetic Resonance ImagingNumbnessOperative ProceduresOperative Surgical ProceduresPEG-DAPalsyParalysedParturitionPatientsPerformancePeripheral nerve injuryPlegiaPolymersPopulationPredispositionPrintingProceduresProcessPrognosisPropertyRecoveryRecovery of FunctionReportingReproducibilityResearchShapesSideSiteSourceSpecific qualifier valueSpecifiedSpinal Cord TraumaSpinal TraumaSpinal cord injuredSpinal cord injuryStructureSurgicalSurgical InterventionsSurgical ProcedureSusceptibilitySystemTechniquesTestingTherapeuticTimeTissue GrowthTranslationsTraumaTraumatic MyelopathyUpper ExtremityUpper LimbValidationVascularizationWorkZeugmatographyage 18age 18 yearsautoimmune conditionautoimmune disorderautoimmunity diseaseautologous graftautotransplantationaxon growthaxon regenerationaxonal growthaxonal regenerationbio-printingbiocompatibilitybiological materialbiomaterial compatibilitybioprintingbirthing individualbirthing patientbirthing peoplechild patientsclinical translationclinically translatablecommercializationcontinuous monitoringdesigndesigningdiabetesdigitaleighteen year oldeighteen years of ageelectrophysiologicalfabricationflexibilityflexiblefunctional recoveryhead/neck injuryhydrogel scaffoldimage guidanceimage guidedimagingimplantable sensorimplanted sensorindividual who gives birthinjuredinjuriesinnovateinnovationinnovativekidsloss of functionmanufacturemeetingmeetingsmeternerve damagenerve injurynerve reconstructionnerve repairnervous system regenerationneuralneural graftneural injuryneural regenerationneuroregenerativenon-human primatenonhuman primateontogenyparalysisparalyticpatient who gives birthpediatricpediatric patientspeople giving birthpeople who birthpeople who give birthperipheral nerve crush injuriesperipheral nerve repairpoly(ethylene glycol)diacrylatepoly(ethyleneglycol) diacrylatepolyethyleneglycol diacrylatepolymerpolymericpre-clinicalpreclinicalreal time monitoringrealtime monitoringregenerated nerveregeneration based therapyregeneration therapyregenerativeregenerative therapeuticsregenerative therapyrepairrepairedscaffoldscaffoldingsciatic nervesciatic nerve injurysensorsexsuccesssurgerythree dimensionalthree dimensional printingtranslationtumorvalidationswirelesswireless monitorwireless sensoryoungster
Description preview
Project Summary
Peripheral nerve injuries, as a result of trauma, tumors, or other medical conditions, require 50,000-200,000
surgeries annually, and may cause complete or partial paralysis. The autograft is the current "gold standard"
but requires additional procedures to harvest the graft, can be challenging to perform in a pediatric population,…
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