grant
Pre-clinical Studies of Therapy for Myelodysplastic Syndrome
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY20251.beta.-D-Arabinofuranosylcytosine5 AZC5-AC5-Aza-cytidine5-Azacytidine5-Azadeoxycytidine5-deoxyazacytidine98 kD Nucleoporin98-kD Gene NucleoporinADIR2AML - Acute Myeloid LeukemiaARA-cellAZCAcute Myeloblastic LeukemiaAcute Myelocytic LeukemiaAcute Myelogenous LeukemiaAlexanAngiogenesis AntagonistsAngiogenesis BlockersAngiogenesis InhibitorsAngiogenetic AntagonistsAngiogenetic InhibitorsAngiogenic AntagonistsAngiogenic InhibitorsAngiostatic AgentsAnti-Angiogenetic AgentsAnti-Angiogenic AgentsAnti-Angiogenic DrugsAntiangiogenesis AgentsAntiangiogenic AgentsAntiangiogenic DrugsApoptosis InhibitorApoptosis Inhibitor GeneArabineArabinofuranosylcytosineArabinosylcytosineAracytidineAracytinAracytineAzacitidineAzacytidineBiologyBlood Precursor CellBone Marrow GraftingBone Marrow TransplantBone Marrow TransplantationC-C-CKR-1CDw128aCMKAR1CRADACXCR1Cell BodyCell LineCell TherapyCellLineCellsCollaborationsCooperative Research and Development AgreementCytarabineCytarabinumCytarbelCytosarCytosar-UCytosarUCytosine ArabinosideCytosine-.beta.-arabinosideDNADNA Methyltransferase InhibitorDecitabineDeoxyazacytidineDeoxyribonucleic AcidDezocitidineDiseaseDisorderDysmyelopoietic SyndromesEngraftmentErpalfaFDA approvedGLFG-Repeat Containing NucleoporinGraft-Versus-Tumor InductionHDAC AgentHDAC inhibitorHematopoiesisHematopoietic Cell TumorHematopoietic Cellular Control MechanismsHematopoietic MalignanciesHematopoietic NeoplasmsHematopoietic Neoplasms including LymphomasHematopoietic Progenitor CellsHematopoietic TumorHematopoietic and Lymphoid Cell NeoplasmHematopoietic and Lymphoid NeoplasmsHematopoietic stem cellsHistocompatibilityHistone Deacetylase InhibitorHistone deacetylase inhibitionIL8R1IL8RAIL8RA geneIL8RBAIndustryInstitutionInvestigatorsIonizing Electromagnetic RadiationIonizing radiationLicensingMalignant Hematopoietic NeoplasmManuscriptsMarrow TransplantationMiceMice MammalsMinorModelingMurineMusMyelodysplastic DiseaseMyelodysplastic SyndromesNUP196NUP96 GeneNUP98NUP98 geneNUP98-NUP96 PrecursorNeoplasmsNeovascularization InhibitorsNuclear Pore Complex Protein NUP98Nucleoporin 98kDNucleoporin NUP98Pharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePre-Clinical ModelPreclinical ModelsPrediction of Response to TherapyPropertyProteinsPublishingRadiation-Ionizing TotalRefractory Anemia with an Excess of BlastsRefractory anaemia with excess blastsResearch PersonnelResearchersRoleSmoldering LeukemiaStrains Cell LinesTarabine PFSTissue CompatibilityToxic effectToxicitiesTransgenesTransplantationUdicilWild Type MouseXenograft Modelacute granulocytic leukemiaacute myeloid leukemiaantiangiogenicblood cancerblood cell formationblood cell progenitorblood progenitorblood stem cellblood-forming stem cellcancer of bloodcancer of the bloodcell based interventioncell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapyconditioningcultured cell linedetermine efficacydrug developmenteffective therapyeffective treatmentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyexperimentexperimental researchexperimental studyexperimentsgraft-versus-tumorhematopoietic progenitorhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellhuman diseasein vivo Modelinhibitorionizing outputkinase inhibitorladakamycinmyelodysplasianeoplasianeoplasm therapyneoplastic growthnovelnuclear pore complex protein 98pharmaceuticalpre-clinical assessmentpre-clinical efficacypre-clinical studypreclinical assessmentpreclinical efficacypreclinical studypredict therapeutic responsepredict therapy responsesmall moleculesocial roletherapy predictiontransgenetransplanttreatment predictiontreatment response predictionwildtype mousexenograft transplant modelxenotransplant model
Description preview
We have modified a previously established in vivo model of myelodysplastic neoplasm (MDS) to now generate mice that have both wild type (WT) and NHD13 (MDS-derived) hematopoiesis by co-transplantation of WT and NHD13 hematopoietic stem cells into WT recipients. We have refined this model to enable transplant of NHD13 MDS hematopoietic cells…
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