grant
Pre- and Postnatal Exposure to Air Pollutants and the Gut Microbiome: Implications for Brain Development in Early and Mid-Childhood
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 10 Mar 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAD/HDADHDASDActive Follow-upAddressAdultAdult HumanAffectAge MonthsAir PollutantsAir PollutionAmino AcidsAmmon HornAnimal ModelAnimal Models and Related StudiesAnxietyArchivesAttention deficit hyperactivity disorderAttenuatedAutismAutistic DisorderBacteroidesBehavioralBile AcidsBirthBlood flowBrainBrain Nervous SystemChildChild YouthChildhoodChildren (0-21)ClostridiumCognitionCognitiveCornu AmmonisCountyDNA seqDNA sequencingDNAseqDataDevelopmentDevelopmental DelayDevelopmental Delay DisordersEarly Infantile AutismEmotionalEncephalonEnvironmental ExposureExposure toFecesFunctional MetagenomicsFundingGI microbiomeGeneralized GrowthGrowthHealthHippocampusHortega cellHumanImpairmentInfantInfantile AutismInflammationInterventionInvestigatorsKanner's SyndromeKnowledgeLanguageLateralLatinoLearning DisabilitiesLearning disabilityLifeLinkLipid PeroxidationLipidsLiteratureLongitudinal StudiesLos AngelesMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMaternal HealthMaternal NutritionMaternal dietMeasuresMediatingMediatorMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMental DepressionMental disordersMental health disordersMetabolic PathwayMetagenomicsMicrogliaModern ManMothersMotorNMR ImagingNMR TomographyNational Institutes of HealthNeural DevelopmentNeurocognitiveNeurodevelopmental DisorderNeurological Development DisorderNuclear Magnetic Resonance ImagingNutritionalOutcomeOxidative StressParietal LobeParturitionPathway interactionsPhysiologyPopulationPredominantly Hyperactive-Impulsive Type Attention-Deficit DisorderPredominantly Hyperactive-Impulsive Type Hyperactivity DisorderProductionPsychiatric DiseasePsychiatric DisorderResearchResearch PersonnelResearchersRestRoleSchool-Age PopulationShort-Chain Fatty AcidsSpecific Child Development DisordersStructureTemporal LobeTestingTissue GrowthUnited States National Institutes of HealthVariantVariationVolatile Fatty AcidsZeugmatographyactive followupadulthoodaminoacidattenuateattenuatesautism spectral disorderautism spectrum disorderautistic spectrum disorderbacteria in the gutbrain MR imagingbrain MRIbrain magnetic resonance imagingbrain tissuecerebral MR imagingcerebral MRIcerebral magnetic resonance imagingcognitive abilitycognitive assessmentcognitive developmentcognitive performancecognitive testingcohortdepressiondevelopmentaldigestive tract microbiomeearly life exposureeconomic costenteric microbiomeexposed in uterofecal metabolomefecal samplefeedingfetal exposurefollow upfollow-upfollowed upfollowupfrontal cortexfrontal lobegastrointestinal microbiomegitter cellgut bacteriagut microbiomegut microbiome of infantgut-associated microbiomehippocampalin utero exposureinfancyinfant gut microbiomeinfantileintestinal biomeintestinal microbiomeintra-uterine environmental exposureintrauterine environmental exposurekidsknowledge baselong-term studylongitudinal outcome studiesmaternal nutrition during pregnancymental illnessmesogliametabolic profilemetabolism measurementmetabolomicsmetabonomicsmicrobialmicroglial cellmicrogliocytemodel of animalmother nutritionmulti-modalitymultidisciplinarymultimodalitymyelinationneonate gut microbiomeneurodevelopmentneurodevelopmental diseaseneurogenesisnewborn gut microbiomenovelnutritiousontogenyparietal cortexpathwaypediatricperivascular glial cellpost-natal periodpostnatalpostnatal periodprenatalprenatal exposureprenatally exposedpreventpreventingprospectivepsychiatric illnesspsychological disorderschool agesocial rolestoolstool samplestool specimensubstantia albatemporal cortexunbornunder served communityunderserved communitywhite matteryoungster
Description preview
ABSTRACT
Early life exposure to air pollution (AP), which disproportionately affects underserved communities, is thought to
disrupt cognitive, emotional, and behavioral development. Human studies show that exposure during the
prenatal and early postnatal periods are associated with developmental delays, autism, more severe attention-
deficit…
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