grant
PQBP1 as a central regulator of inflammation in neurodegenerative diseases
Organization SCRIPPS RESEARCH INSTITUTE, THELocation LA JOLLA, UNITED STATESPosted 1 Feb 2025Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2025AD dementiaAdaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAddressAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's brainAlzheimer's disease brainAlzheimers DementiaAmmon HornAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAssayAβBindingBinding ProteinsBioassayBiologicalBiological AssayBrainBrain Nervous SystemCNS Nervous SystemCapsidCapsid ProteinsCell BodyCell Culture TechniquesCell FunctionCell PhysiologyCell ProcessCell modelCellsCellular FunctionCellular PhysiologyCellular ProcessCellular injuryCellular modelCentral Nervous SystemChargeChronicCoat ProteinsCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplementComplement ProteinsComplexConfocal MicroscopyCore FacilityCornu AmmonisCyclic GMPCyclicityCytoplasmDNADNA ReplicationDNA SynthesisDNA biosynthesisDataDegenerative Neurologic DisordersDeoxyribonucleic AcidDependenceDevelopmentDimerizationDiseaseDisease MarkerDisorderDisturbance in cognitionEncephalonEnsureEnvironmentEventExtracellular SpaceFISH TechnicFISH TechniqueFISH analysisFISH assayFTD dementiaFluorescence In Situ HybridizationFluorescent in Situ HybridizationFrontal Temporal DementiaFrontotemporal DementiaFutureGuanosine Cyclic MonophosphateHIV-1HIV-IHIV1HippocampusHortega cellHumanHuman Immunodeficiency Virus Type 1Human immunodeficiency virus 1ImmuneImmune responseImmunesImmunofluorescenceImmunofluorescence ImmunologicImmunomodulationImpaired cognitionImpairmentIn VitroInfectionInflammationInflammatoryInflammatory ResponseInnate Immune SystemInnate ImmunityIntercellular SpaceKnowledgeLigand Binding ProteinLigand Binding Protein GeneLinkMT-bound tauMediatingMicrogliaModalityModelingModern ManMolecularMolecular InteractionNAC precursorNative ImmunityNatural ImmunityNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeuraxisNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurodevelopmental DisorderNeurologic Degenerative ConditionsNeurological Development DisorderNeuron DegenerationNeuronsNon-Specific ImmunityNonspecific ImmunityPARK1 proteinPARK4 proteinPathogenesisPathologicPathologyPathway interactionsPatientsPatternPattern recognition receptorPeriodicityPlayPoly QPrevalencePrimary Senile Degenerative DementiaProline-Rich DomainProline-Rich RegionProtein BindingProtein DimerizationProteinsPublic HealthPublishingReagentReceptor ProteinReportingResearchResearch InstituteRhythmicityRoleSNCASNCA proteinScanningSeriesSiteStaining methodStainsSubcellular ProcessTLR proteinTauopathiesTechniquesTherapeuticTherapeutic InterventionToll-Like Receptor Family GeneToll-like receptorsTrainingValidationViral Coat ProteinsViral DiseasesViral Outer Coat ProteinVirus Diseasesa beta peptidea-syna-synucleinabetaabeta accumulationabeta aggregationabnormally aggregated tau proteinadapter proteinalpha synucleinalpha synuclein genealphaSP22amyloid betaamyloid beta accumulationamyloid beta aggregationamyloid β accumulationamyloid β aggregationamyloid-b proteinasynaβ accumulationaβ aggregationbeta amyloid fibrilbiologicbound proteinbrain tissuecGMPcell culturecell culturescell damagecell injurycellular damagecognitive dysfunctioncognitive losscomplement systemcomplementationdamage to cellsdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentalexperiencefilamentous tau inclusionfront temporal dementiafrontal lobe dementiafrontotemporal lobar degeneration dementiafrontotemporal lobar dementiafrontotemporal lobe degeneration associated with dementiagitter cellglial activationglial cell activationhippocampalhost responseimmune modulationimmune regulationimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseinflammation markerinflammatory markerinjury to cellsinnovateinnovationinnovativeinsoluble aggregateintervention therapymesogliamicroglial cellmicrogliocytemicrotubule associated protein tau aggregationmicrotubule associated protein tau depositmicrotubule bound taumicrotubule-bound taumonomermouse modelmurine modelmutantnanoneural degenerationneural inflammationneurodegenerationneurodegenerativeneurodegenerative illnessneurodevelopmental diseaseneuroinflammationneuroinflammatoryneurological degenerationneuronalneuronal degenerationneuropathologic tauneuropathological tauneurotoxicnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnon A-beta component of AD amyloidnon A4 component of amyloid precursornovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpaired helical filament of taupathwayperivascular glial cellpolyQpolyglutamatepolyglutamineprimary degenerative dementiaprogramsprotein aggregateprotein aggregationprotein protein interactionreceptorrecruitresponseself-aggregate tausenile dementia of the Alzheimer typesensorsocial rolesoluble amyloid precursor proteinsuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttautau PHFtau Proteinstau accumulationtau aggregatetau aggregationtau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau fibrillizationtau filamenttau induced degenerationtau induced neurodegenerationtau interactiontau mediated neurodegenerationtau neurodegenerative diseasetau neurofibrillary tangletau neuropathologytau oligomertau paired helical filamenttau pathologytau pathophysiologytau polymerizationtau proteinopathytau related neurodegenerationtau-induced pathologytau-tau interactiontauopathic neurodegenerative disordertauopathyvalidationsviral DNAviral infectionvirus DNAvirus infectionvirus-induced diseaseα synuclein geneα-synα-synucleinτ Proteinsτ aggregationτ interaction
Description preview
PROJECT SUMMARY:
Neurodegenerative diseases pose significant challenges to public health and our understanding of brain function.
Central to these conditions is the pathological accumulation of protein aggregates, notably alpha-synuclein, beta-
amyloid, and Tau. Specifically, Tau aggregates are expelled into the extracellular space as neurons…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click