grant
Powassan virus evolution, fitness, and pathogenesis in the Northeast and Midwest United States
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20250-11 years oldAddressAffectBiologyBlack-legged TickBrainBrain InflammationBrain Nervous SystemCanadaCase Fatality RatesCell LineCellLineChildChild YouthChildren (0-21)ClinicalCompetenceConnecticutDataDeerDeer TickDiseaseDisorderEmerging Communicable DiseasesEmerging Infectious DiseasesEncephalitisEncephalonEntomologyEuropeEvolutionFlavivirusFrequenciesFutureGene variantGenetic DiversityGenetic StructuresGenetic VariationGenomicsGenotypeGeographyGoalsGroup B ArbovirusHealthHistoryHumanHuman BitesI scapularisI. scapularisIn VitroInfectionInfectious disease threatInfrastructureIx scalpularisIx. scapularisIxodesIxodes damminiIxodes scapularisIxodes tickIxodidaKnowledgeLaboratoriesLaboratory StudyLaboratory miceLinkMetadataMiceMice MammalsMidwestMidwest U.S.Midwest USMidwestern United StatesMinnesotaModern ManMurineMusNIAIDNational Institute of Allergy and Infectious DiseaseNational Institutes of HealthNeurologicNeurologicalNew EnglandNew YorkNortheastern United StatesOrthoflavivirusPathogenesisPatternPhenotypePhylogenetic AnalysisPhylogeneticsPopulationPositionPositioning AttributePowassanPowassan virusPreventionPublic HealthRecording of previous eventsReportingResearch SpecimenRiskRussiaSamplingSerology testSpecimenStrains Cell LinesSurveillance ProgramSurvivorsSystemTailTestingTick-Borne DiseasesTick-Borne Encephalitis VirusTickborne Encephalitis VirusTicksTransmissionUnited StatesUnited States National Institutes of HealthVariantVariationViralViral GeneticsViral GenomeVirulenceVirusWhite-Footed MouseWisconsinallelic variantarboviral diseasearbovirus diseasearthropod-borne diseasearthropodborne diseaseblacklegged tickcross-species spillovercross-species transmissioncultured cell linedisease heterogeneitydisease riskdisorder riskfield based datafield learningfield studyfield testfitnessfuture outbreakgenetic variantgenomic varianthistorieshost jumphost switchingimprovedinterspecies transmissionkidsmeta datanext outbreakoutbreak in the futurepressureresponseserology assaytick populationtick-bornetick-borne flavivirustick-borne illnesstickbornetickborne diseasetickborne flavivirustickborne illnesstransmission across speciestransmission between speciestransmission processtransmitted across speciestransmitted between speciestransmitted cross-speciesvector competencevector tickvectorial competenceviral genomicsviral transmissionvirologyvirus geneticsvirus genomevirus genomicsvirus transmissionyoungster
Description preview
Project Summary
Tick-borne Powassan virus (POWV) is an emerging public health threat, but has been understudied to date.
Since its discovery in 1958, human cases of POWV have been reported in the United States, Canada, and
Russia. Starting in 2006, confirmed cases of POWV have increased in both frequency and scope in New
England and the Upper…
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