grant
Potentials of Epigenetic Molecules in Attenuating the Phenotypes of Periodontitis
Organization TUFTS UNIVERSITY BOSTONLocation BOSTON, UNITED STATESPosted 15 Jun 2023Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY202621+ years old3' Untranslated Regions3'UTRAdultAdult HumanAffinityAgeAlveolar Bone LossAlveolar ResorptionAmericanAreaBET bromodomain inhibitorBET inhibitorBETiBM Stem CellBM derived progenitorBM progenitorBM- derived Stem CellsBasal Transcription FactorBasal transcription factor genesBeta Cadherin-Associated ProteinBeta-1 CateninBindingBiocompatible MaterialsBiologicalBiologyBiomaterialsBody TissuesBone FormationBone Marrow Stem CellBone Marrow progenitorBone RegenerationBone ResorptionBromodomainBromodomain and Extra-Terminal motif inhibitorBromodomains and extra-terminal domain inhibitorCUL-2CausalityCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell FunctionCell Growth in NumberCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCellular ProliferationCellular biologyChronic PeriodontitisClinicClinical TrialsCrossbreedingDNA Molecular BiologyDNA TherapyDiseaseDisease ProgressionDisorderDoseDrug DeliveryDrug Delivery SystemsDrug KineticsDysfunctionEndogenous FactorsEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEtiologyExperimental PathologyFoundationsFunctional RNAFunctional disorderGene DeletionGene ExpressionGene TranscriptionGene Transfer ClinicalGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic HybridizationGenetic InterventionGenetic TranscriptionGoalsGum DiseaseImmune Complex DiseasesImmunologyIndividualInflammationInflammatoryInflammatory ResponseInjectionsIntracellular Communication and SignalingInvestigationKO miceKnock-out MiceKnockout MiceKnowledgeLaboratoriesLytotoxicityMacrophageMassachusettsMeasurementMediatingMiceMice MammalsMicroRNAsModelingModificationMolecularMolecular BiologyMolecular InteractionMurineMusMφNatural regenerationNoncoding RNANontranslated RNANull MouseOsteoblastsOsteoclastic Bone LossOsteoclastsOsteogenesisOutcome MeasurePRO2286Palliative CarePalliative TherapyPalliative TreatmentParadentiumParodontosisPathogenesisPathologicPathway interactionsPatientsPeptide DomainPeriodontal Bone LossPeriodontal DiseasesPeriodontal ResorptionPeriodontitisPeriodontiumPharmacodynamicsPharmacokineticsPhenotypePhysiopathologyPopulationProtein DomainsProtein InhibitionRNA ExpressionRegenerationRegulator GenesReportingResistanceRibosomal DNARodentRodentiaRodents MammalsRoleSeverity of illnessSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteStructureSubcellular ProcessSystemTechnologyTertiary Protein StructureTherapeuticTherapeutic AgentsTimeTissuesToothTooth LossTooth Supporting StructuresTooth structureTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional Regulatory ElementsTransgenic MiceTreatment EfficacyType III HypersensitivityUntranslated RNAadulthoodagesalveolar bonealveolar supporting bonebeta catbeta cateninbiologicbiological materialbiological signal transductionbonebone marrow derived progenitorbone marrow derived stem cellsbone marrow stromal cellbone marrow stromal stem cellbone massbone tissue formationbromodomain extra-terminal inhibitorcausationcell biologycell typecellular differentiationcomfort carecytokinecytotoxicitydesigndesigningdisease causationdisease severityepigenetic therapyepigeneticallyexperiencefALSfamilial ALSfamilial amyotrophic lateral sclerosisgene deletion mutationgene manipulationgene repair therapygene therapeuticsgene therapygene-based therapeuticgene-based therapeuticsgene-based therapygenes therapeuticgenes therapeuticsgenetic elementgenetic manipulationgenetic therapygenetic trans acting elementgenetically manipulategenetically perturbgenomic therapyhealinghuman diseaseiPSiPSCiPSCsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinhibit proteininhibit proteinsinhibitorinnovateinnovationinnovativeintervention efficacyinventionmaxilla alveolar processmeasurable outcomemiRNAmouse modelmurine modelnanonano particlenano-sized particlenanomaterialsnanoparticlenanosized particlenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnoncodingnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyosteoclastogenesisoutcome measurementoverexpressoverexpressionpalliative interventionpathophysiologypathwayperiodontal disorderperiodontium diseaseperiodontium disorderprotein inhibitionsrDNAregenerateregenerate boneregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueregenerativeregulatory generesistantscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillssocial rolesocket wallteeththerapeutic efficacytherapeutic genetherapy efficacytissue regenerationtissue regrowthtissue renewaltissue specific regenerationtrans acting elementtranscription factortranscriptomicstranslational studyβ-catenin
Description preview
Periodontal disease represents one of the most prevalent diseases in adult population as 47% of
Americans over age 30 have the disease. Periodontitis is a complex immune and inflammatory disease,
characterized by three major pathological features: exacerbating inflammatory response, excess
osteoclastic alveolar bone resorption and decreased…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click