grant
Posttranslational regulation of macropinocytosis in pancreatic cancer
Organization PURDUE UNIVERSITYLocation WEST LAFAYETTE, UNITED STATESPosted 28 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY20254-SphingenineAccelerationAddressAmino Acid ChannelAmino Acid Transport SystemsAmino Acid TransporterAmino AcidsAttenuatedC-K-RASCancer BiologyCancer CauseCancer EtiologyCancersCell Communication and SignalingCell DeathCell SignalingCell SurvivalCell ViabilityCellular RegulationCessation of lifeComplexDataDeathDiseaseDisorderEnvironmentEnzyme GeneEnzymesEpithelial CellsEssential Amino AcidsEventExhibitsExtracellular FluidGeneralized GrowthGeneticGlnGlutamineGoalsGrowthGrowth Factor ReceptorsHumanIn VitroIntracellular Communication and SignalingK-RAS2AK-RAS2BK-RasK-Ras 2AK-Ras-2 OncogeneKRASKRAS driven oncogenesisKRAS oncogenesisKRAS-driven tumorigenesisKRAS-mediated tumorigenesisKRAS2KRAS2 geneKi-RASKinasesKnowledgeL-GlutamineLesionLipidsLysosomesMalignant CellMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant neoplasm of pancreasMediatingMediatorMetabolicMetabolic PathwayMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorModern ManMonomeric G-ProteinsMonomeric GTP-Binding ProteinsMutateNeoplasm MetastasisNutrientOncogene K-RasOncogenicPDA modelPDAC ModelPDAC cancer cellPDAC cellPancreasPancreas CancerPancreas Ductal AdenocarcinomaPancreaticPancreatic CancerPancreatic Ductal AdenocarcinomaPathway interactionsPatientsPhenotypePhosphatasesPhosphohydrolasesPhosphomonoesterasesPhosphoprotein PhosphatasePhosphoprotein Phosphatase-2CPhosphoprotein PhosphohydrolasePhosphoric Monoester HydrolasesPhosphorylationPhosphorylation SitePhosphotransferase GenePhosphotransferasesPlayPost-Translational RegulationPosttranslational RegulationProcessPropertyProtein Phosphatase CProtein Phosphatase GeneProtein Phosphatase-1Protein Phosphatase-2AProtein PhosphorylationProtein phosphataseQ LevoglutamideQ. LevoglutamideRASK2RegulationResistanceRoleSecondary NeoplasmSecondary TumorSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSmall G-ProteinsSmall GTPasesSphingosineStressSurvival RateTestingTherapeuticTissue GrowthTransphosphorylasesUnited StatesUpregulationVesicleaminoacidanalogantagonismantagonistattenuateattenuatesbiological signal transductioncancer cellcancer metastasiscancer microenvironmentcancer progressioncancer survivalcell growth regulationdrug discoveryin vivoinhibitormalignancymouse modelmurine modelmutantnecrocytosisneoplasm progressionneoplasm/cancerneoplastic progressionnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetnutrient deprivationnutritional deprivationoncogenic KRASontogenypancreatic cancer patientspancreatic ductal adenocarcinoma cellpancreatic ductal adenocarcinoma modelpancreatic malignancypathwaypatients with pancreatic cancerpharmacologicpreventpreventingresistance mechanismresistance to therapyresistantresistant mechanismresistant to therapyresponsesocial rolesynergismtherapeutic resistancetherapeutic targettherapy resistanttreatment resistancetumortumor cell metastasistumor growthtumor microenvironmenttumor progressionv-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog
Description preview
The majority of pancreatic ductal adenocarcinoma (PDAC) patients present with late-stage, metastatic disease
that is often resistant to therapeutics, resulting in the lowest survival rate of all major cancers. Metabolic rewiring
in response to oncogenic signals plays a critical role in PDAC cell survival, tumor growth, and metastasis. In
contrast…
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