grant

Post-Transcriptional Regulation of Lung Fibrosis.

Organization UNIVERSITY OF ALABAMA AT BIRMINGHAMLocation BIRMINGHAM, UNITED STATESPosted 5 Sept 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025Adhesion PlaquesApoptoticBleoBleomycinBody TissuesCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell SignalingCell-Extracellular MatrixCell-Matrix Adherens JunctionsCellsCellular MatrixCold-Insoluble GlobulinsCollagenCytoplasmic ProteinCytoskeletal SystemCytoskeletonDataDepositDepositionDiseaseDisorderDown-RegulationECMExtracellular MatrixExtracellular Matrix ProteinsFN1FibroblastsFibronectin 1FibronectinsFibrosing AlveolitisFibrosisFocal AdhesionsFocal ContactsFosteringGene Action RegulationGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenetic TranscriptionGoalsHumanImpairmentIntegrinsIntegrins Extracellular MatrixIntracellular Communication and SignalingLETS ProteinsLarge External Transformation-Sensitive ProteinLungLung Respiratory SystemLung Tissue FibrosisMediatingMessenger RNAMiceMice MammalsModern ManMolecularMurineMusMyofibroblastOpsonic GlycoproteinOpsonic alpha(2)SB GlycoproteinPathologicPlayPost-Transcriptional ControlPost-Transcriptional RegulationProductionProfibrotic factorProfibrotic signalProtein DeficiencyProteinsPulmonary FibrosisRNA ExpressionRNA SplicingRNA StabilityReactionRegulatory ProteinRoleSignal TransductionSignal Transduction SystemsSignalingSplicingTestingTissuesTranscriptionWild Type Mousealpha 2-Surface Binding Glycoproteinbiological signal transductioncellular differentiationcrosslinkdeficiency of proteindiffuse interstitial pulmonary fibrosisdriving forceeffective therapyeffective treatmentfibrogenesisfibrosis in the lunggenetic regulatory proteinidiopathic pulmonary fibrosisin vivointracellular skeletonloss of functionlung fibrosismRNAnovelpost-transcriptional gene regulationposttranscriptionalprotein expressionprotein functionrecruitregulatory gene productresponsesocial rolewildtype mouse
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PROJECT SUMMARY/ABSTRACT
Idiopathic pulmonary fibrosis (IPF) is a fatal progressive fibrotic disease characterized with excessively deposited

extracellular matrix (ECM) proteins. Persistent myofibroblast activation is considered as one of driving forces

that lead to excessive ECM protein production and fibrosis in IPF. The molecular mechanisms…

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Post-Transcriptional Regulation of Lung Fibrosis. — UNIVERSITY OF ALABAMA AT BIRMINGHAM | UNITED STATES | Sept 2023 | Dev Procure