grant
Post-transcription Initiation Control of Gene Expression
Organization PENNSYLVANIA STATE UNIVERSITY, THELocation UNIVERSITY PARK, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AffectAmino AcidsB subtilisB. subtilisBacillus subtilisBase PairingBindingBinding SitesBioinformaticsCareer ChoiceCareer PathCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessChaperoneCirculatory CollapseCombining SiteComputer AnalysisDNA-Dependent RNA PolymerasesDNA-Directed RNA PolymeraseDevelopmentE coliE. coliEscherichia coliGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGenesGoalsGrantHealthHeavy MetalsHigh temperature of physical objectHumanIn VitroMapsMediatingMessenger RNAMethodsMicrobiologyModern ManMolecularMolecular ChaperonesMolecular InteractionNon-Polyadenylated RNANucleic Acid Biochemistry, RNA - Ribonucleic AcidOrganismParentsProcessProductivityProteinsRNARNA BiochemistryRNA Gene ProductsRNA HelicaseRNA Nucleic Acid BiochemistryRNA PolymerasesRNA SeqRNA sequencingRNA-Binding ProteinsRNAseqReactive SiteRegulationResearchRibonucleic AcidRibosomesShockSmall RNAStressStructureSubcellular ProcessSystemThermometersTrainingTranscription InitiationTranslationsaminoacidantiterminationattenuationcareercareer aspirationcareer interestcareer pathwaycareer trackcell typecirculatory shockcomputational analysescomputational analysiscomputer analysesdevelopmentalexperienceexperimentexperimental researchexperimental studyexperimentsgenome scalegenome-widegenomewideglobal gene expressionglobal transcription profilehigh temperaturehuman diseaseimprovedin vivoinsightliving systemmRNAmutantnovelparentposttranscriptionalshockstranscription terminationtranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicstranslation
Description preview
Project Summary/Abstract
A unifying theme of this research is to determine how RNA structure and RNA-binding proteins regulate
gene expression by affecting the activity of RNA polymerase (RNAP) or by affecting ribosome access to the
mRNA. Critical mechanistic insight into these processes will be obtained through studies in Escherichia coli and…
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