grant
Post-initiation control of Pseudomonas aeruginosa exopolysaccharide biosynthesis operons
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AcuteAlginatesAnabolismAntibiotic AgentsAntibiotic DrugsAntibioticsApplications GrantsAssayB subtilisB. subtilisBacillusBacillus subtilisBacteriaBacteroidetesBasal Transcription FactorBasal transcription factor genesBindingBioassayBiochemicalBiologicalBiological AssayCapsulesCell Communication and SignalingCell SignalingCell-Extracellular MatrixCellular AssayChronicColiform BacilliCommunitiesComplexCouplingCystic FibrosisDNADNA-Dependent RNA PolymerasesDNA-Directed RNA PolymeraseDataDedicationsDeoxyribonucleic AcidDependenceDisinfectantsDistalE coliE. coliECMElongation FactorEnabling FactorsEnsureEnteric BacteriaEnterobacteriaEnterobacteriaceaeEnzyme GeneEnzymesEscherichia coliEventExclusionExtracellular MatrixFamilyFilamentFutureGene ClusterGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic TranscriptionGlycansGrant ProposalsHistonesHousekeepingHouseworkImmuneImmune systemImmunesImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunosuppressed HostIndividualIntracellular Communication and SignalingKineticsLipopolysaccharidesLogicMediatingMicrobial BiofilmsMiscellaneous AntibioticModificationMolecular InteractionMucoviscidosisMyxococcusNatural ProductsNon-Polyadenylated RNANucleoproteinsOperonP aeruginosaP. aeruginosaPathogenesisPathway interactionsPersonsPhylogenetic AnalysisPhylogeneticsPneumoniaPolymersPolysaccharidesProductionProductivityProteinsPseudomonas aeruginosaPseudomonas pyocyaneaPublishingRNARNA ExpressionRNA Gene ProbesRNA Gene ProductsRNA HelicaseRNA PolymerasesRNA ProbesRegulationReporterResearchResistanceRibonucleic AcidRibosomesSepsisSignal TransductionSignal Transduction SystemsSignalingStressStructureSurfaceSurgical Wound InfectionSystemT thermophilusT. thermophilusTestingTextbooksThermus thermophilusTranscriptionTranscription ElongationTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTranslatingTranslationsUrinary tract infectionUrinary tract infectious diseaseanti-microbialantimicrobialantiterminationbiofilmbiologicbiological signal transductionbiosynthesiscapsulecell assayexperienceexperimentexperimental researchexperimental studyexperimentsgenome scalegenome-widegenomewidehuman pathogenimmunosuppressed patientin vitro Assayin vivoinsightnaturally occurring productopportunistic pathogenparalogparalogous genepathwaypolymerpolymericprematureprematuritypromoterpromotorrecruitresistantrhosuccesssurgical site infectiontermination factortranscription factortranscription terminationtranslationurinary infection
Description preview
SUMMARY
Pseudomonas aeruginosa is a ubiquitous opportunistic pathogen that causes acute and chronic
pneumonia, sepsis, urinary tract infections, and surgical-site infections. Its success as a human pathogen
is due in large part to its ability to form biofilms, which confer resistance to the host immune system,
antibiotics, and other stresses.…
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