grant
Post-Infectious Dysautonomia: Insights into Clinical Phenotypes and Disease Pathogenesis
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2025ACh ReceptorsAcetylcholine ReceptorsAcuteAffectAfter CareAfter-TreatmentAftercareAnalgesia TestsAutoantibodiesAutoantigensAutologous AntigensAutonomic DysfunctionAutonomic nervous systemAwardB burgdorferiB. burgdorferiBiological MarkersBiometricsBiometryBiostatisticsBorrelia burgdorferiBorrelia burgdorferi sensu strictoBorreliella burgdorferiCOVID crisisCOVID epidemicCOVID pandemicCOVID-19COVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 yearsCV-19Cardiac ChronotropismCell DeathCerebrumCholinergic ReceptorsCholinoceptive SitesCholinoceptorsChronicClinicClinicalClinical ResearchClinical StudyClinical TrialsCluster AnalysesCluster AnalysisCognitiveCoronavirus Infectious Disease 2019CutaneousDataDermatologic biopsyDisablingDiseaseDisease MarkerDisease ProgressionDisorderDizzinessDoppler Transcranial SonographyDysautonomiasDysfunctionELISAEnsureEnzyme-Linked Immunosorbent AssayEvaluationFarr AssayFatigueFc ReceptorFiberFunctional disorderHeart RateHistoryIGIVIV ImmunoglobulinsIVIGImmune MarkersImmune Modulation TherapyImmune PrecipitationImmune globulin IVImmunologic MarkersImmunologyImmunomodulationImmunoprecipitationImmunotherapeutic agentInfectionInterstitial CystitisInterventionIntravenous AntibodiesIntravenous IGIntravenous Immune GlobulinIntravenous ImmunoglobulinsLaboratoriesLack of EnergyLearningLeftLifeLong COVIDLong COVID-19Long coronavirus diseaseLong coronavirus disease 2019Lyme BorreliosisLyme DiseaseLyme Disease SpirocheteMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasurableMediatingMentorshipNerveNerve CellsNerve FibersNerve UnitNeural CellNeurocyteNeuronsNeuropathyNeurosciencesNociception TestsOutcomeOutcome MeasurePASCPNS DiseasesPain AssessmentPain MeasurementPain measurePathogenesisPathogenicityPathologicPathway interactionsPatient Outcomes AssessmentsPatient Reported MeasuresPatient Reported OutcomesPatientsPerfusionPeripheral Nerve DiseasesPeripheral Nervous System DiseasesPeripheral Nervous System DisordersPeripheral NeuropathyPersonsPhenotypePhysiciansPhysiopathologyPost Acute Sequelae of COVID19Post Acute Sequelae of SARS-CoV-2Post Acute Sequelae of SARS-CoV2Post Acute Sequelae of severe acute respiratory syndrome coronavirus 2Post-Acute Sequelae of SARS-CoV-2 InfectionPostural Orthostatic Tachycardia SyndromePostural Tachycardia SyndromePrevalenceQuestionnairesRadioimmunoprecipitation AnalysesRadioimmunoprecipitation AnalysisRadioimmunoprecipitation AssayRecording of previous eventsResearchResearch ResourcesResourcesSARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 pandemicSARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSchoolsScientistSelf-AntigensSevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicSeveritiesSeverity of illnessSubgroupSweat GlandsSympathetic GangliaSymptom BurdenSymptomsSyndromeTestingTherapeuticTilt-Table TestTimeTranscranial Doppler UltrasonographyTranslational Research EnterpriseUnited StatesUniversitiesVasomotorVinculinWorkacute infectionadverse sequelae of COVIDadverse sequelae of COVID-19adverse sequelae of coronavirus diseaseadverse sequelae of coronavirus disease 2019antibody receptorautoimmune antibodyautoimmune attackautoimmune destructionautoimmune pathogenesisautoreactive antibodybio-markersbiologic markerbiomarkerbladder pain syndromecalponincareercerebralchronic COVIDchronic COVID-19chronic COVID-19 sequelaechronic novel coronavirus disease 2019chronic symptomclinical phenotypeclinical significanceclinically significantcohortcoronavirus disease 2019coronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19coronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccoronavirus infectious disease-19cutaneous biopsydensitydisabling symptomdisease severitydisease subgroupsdisease subtypedisorder subtypedysmotilitydysmotility syndromeenzyme linked immunoassayexperiencegastrointestinalhemodynamicshistopathologic examinationhistopathological examinationhistoriesimmune drugsimmune modulationimmune modulatory therapiesimmune modulatory treatmentimmune regulationimmune regulation therapyimmune regulation treatmentimmune regulatory therapyimmune-based biomarkersimmune-based therapeuticsimmune-modulation treatmentimmunologic reactivity controlimmunologic therapeuticsimmunological biomarkersimmunological markersimmunomodulation therapyimmunomodulation treatmentimmunomodulator therapiesimmunomodulator treatmentimmunomodulator-based therapiesimmunomodulatoryimmunomodulatory biologicsimmunomodulatory therapiesimmunomodulatory treatmentimmunoregulationimmunoregulatoryimmunoregulatory therapyimmunoregulatory treatmentimmunotherapeuticsimmunotherapy agentimprovedinsightlong haul COVIDlong haul COVID-19long haul coronavirus diseaselong haul coronavirus disease 2019long haul sequelae of COVID-19long haul sequelae of coronavirus disease 2019long-hauler COVIDlong-hauler COVID-19long-hauler coronavirus disease 2019long-hauler syndromelong-term COVIDlong-term COVID-19long-term coronavirus diseaselong-term coronavirus disease 2019long-term sequelae of COVID-19long-term sequelae of SARS-CoV-2long-term sequelae of coronavirus disease 2019long-term sequelae of severe acute respiratory syndrome coronavirus 2lyme spirochetemeasurable outcomemetavinculinmotility disordernecrocytosisnerve damageneuronalneuropathicneuropathic painnoveloutcome measurementpain assaypainful bladder syndromepainful neuropathypathogenic autoantibodiespathophysiologypathwaypatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespatient variabilitypatient variationpersistent COVID-19persistent symptompost COVID syndromepost COVID-19 sequelaepost COVID-19 syndromepost acute COVID syndromepost acute COVID-19post acute COVID-19 syndromepost acute SARS-CoV-2post acute coronavirus disease 2019post acute coronavirus disease 2019 syndromepost acute coronavirus disease syndromepost acute sequelae following COVID-19post acute severe acute respiratory syndrome coronavirus 2post coronavirus disease 2019 syndromepost coronavirus disease syndromepost treatmentpost-acute phases of COVID-19post-acute sequelae following SARS-CoV-2 infectionpost-acute sequelae of COVID-19post-acute sequelae of acute COVID infectionpost-acute sequelae of coronavirus disease 2019post-orthostatic tachycardiapostural orthostatic tachycardiaprofessorprolonged COVID-19 symptomsprospectiveradioimmunoprecipitationrate of changeself reactive antibodysevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicskillsskin biopsysuccesssudiferous glandtherapeutic immunomodulationtherapeutic immunoregulationtranscranial doppler ultrasoundtranslation research enterprisetranslational research programvariability between patientsvariation between patients
Description preview
PROJECT SUMMARY/ABSTRACT
Dysautonomia, or autonomic nervous system dysfunction, is a common and disabling post-infectious syndrome
that can occur following COVID-19 and Lyme disease. Dysautonomia accounts for many of the symptoms in
Post-Acute Sequelae of COVID-19 (PASC, also called Long COVID) and Post-Treatment Lyme Disease (PTLD,
also called…
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