grant
Population genomics in peripartum cardiomyopathy
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 17 Sept 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AccountingAddressAfricanAfrican ancestryAfrican descentAreaBlackBlack raceBlood SampleBlood specimenCD36CD36 geneCardiacCardiac infarctionCardiomyopathiesCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCaucasianCaucasian RaceCaucasiansCaucasoidCaucasoid RaceCessation of lifeClassificationClinicalComplexCongestive CardiomyopathyDNA mutationDataData SetDeathDilated CardiomyopathyDiseaseDisorderDisparitiesDisparityDisproportionate number of femalesDisproportionate number of womenDisproportionately affects femalesDisproportionately affects womenDisproportionately impacts femalesDisproportionately impacts womenDisproportionately in femalesDisproportionately in womenEarly DiagnosisEuropeanGP3BGP4GPIVGWA studyGWASGene FrequencyGene variantGenerationsGenesGeneticGenetic ChangeGenetic DiversityGenetic PredispositionGenetic Predisposition to DiseaseGenetic RiskGenetic SusceptibilityGenetic VariationGenetic defectGenetic mutationGenetic propensityGenomeGenomicsGestationHealthHeart VascularHeart failureHeritabilityHeterozygoteHomozygoteIncidenceIndividualIndividual DifferencesInherited PredispositionInherited SusceptibilityInternationalInvestigationLate pregnancyLeft Ventricular DysfunctionLifeLinkMaternal MortalityMothersMutationMyocardialMyocardial DiseasesMyocardial DisorderMyocardial InfarctMyocardial InfarctionMyocardial depressionMyocardial dysfunctionMyocardiopathiesMyocardiumNonsense MutationOccidentalOutcomeParticipantPathogenicityPatientsPerinatalPeripartumPersonal SatisfactionPersonsPhenotypePhysiologicPhysiologicalPopulationPost-partum cardiomyopathyPostpartum PeriodPostpartum cardiomyopathyPredispositionPregnancyPregnancy ComplicationsPreventionProteinsRegistriesRiskRisk AssessmentRisk FactorsRisk-associated variantSCARB3SES disparitySeveritiesStandardizationStressSusceptibilitySystematicsSystolic heart failureTestingVariantVariationWomanallelic frequencyallelic variantancestry analysisbiobankbiorepositorycardiac dysfunctioncardiac failurecardiac imagingcardiac infarctcardiac musclecardiac scanningcirculatory systemclinical riskcohortcomplications during pregnancycoronary attackcoronary infarctcoronary infarctionearly detectionexome sequencingexome-seqfamilial cardiomyopathyfemale biasfemale predominancefemale preponderancegenetic analysisgenetic cardiomyopathygenetic etiologygenetic mechanism of diseasegenetic variantgenetic vulnerabilitygenetically predisposedgenome mutationgenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studygenomic biomarkergenomic markergenomic variantheart attackheart dysfunctionheart imagingheart infarctheart infarctionheart muscleheart scanninghereditary cardiomyopathyheterozygosityinherited cardiomyopathyleft ventricle abnormalityloss of functionloss of function mutationlow-frequency mutationmaternal deathmyocardium diseasemyocardium disordernon-sense mutationnovelperipartum cardiomyopathyphenotypic datapolygenetic risk scorespolygenic predictorspolygenic risk scorepolygenic scorespost-partumpredominance in femalespredominance in womenpregnancy-related complicationsprematureprematuritypreventpreventingrare allelerare conditionrare mutationrare syndromerare variantrecruitrisk allelerisk generisk genotyperisk locirisk locusrisk stratificationrisk variantsocio-economic disparitysocio-economic inequalitysocio-economic inequitysocioeconomic disparitysocioeconomic inequalitysocioeconomic inequitystratify riskstressortraitwell-beingwellbeingwhite racewhole genome association analysiswhole genome association studywomen's predominancewomen's preponderance
Description preview
PROJECT SUMMARY
Peripartum cardiomyopathy (PPCM) is a form of heart failure characterized by left ventricular dysfunction
that occurs during late pregnancy or shortly after delivery. This condition causes a sudden weakening of the
heart muscle, leading to clinical heart failure and significant reductions in both quality and quantity of life. PPCM…
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