grant
Pollutant-adsorbed nanoplastics (PANs): the influence of physicochemical properties on biodistribution and brain toxicity following inhalation
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 14 Apr 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026AddressAdsorptionAdventitial CellAffinityAgricultureAstrocytesAstrocytusAstrogliaBBB crossingBindingBioavailabilityBiodistributionBiologicalBiological AvailabilityBlood - brain barrier anatomyBlood-Brain BarrierBody TissuesBrainBrain Nervous SystemCalibrationChemicalsChlorpyrifosComplexDarknessDataData SetDegradation PathwayDegradative PathwayDetectionDevelopmentDiazinonDimpylateEncephalonEndothelial CellsEnvironmentExposure toFoundationsGenerationsGenesGuidelinesHealthHemato-Encephalic BarrierHg elementHumanHuman FigureHuman bodyIR/UV/Raman SpectroscopyImageImaging ProceduresImaging TechnicsImaging TechniquesIn VitroIndividualIndustrializationInhalationInhalingKineticsKnowledgeLabelLeadLungLung Respiratory SystemMapsMercuryMethodologyMethodsMicroplasticsModelingModern ManMolecularMolecular InteractionNerve CellsNerve UnitNeural CellNeurocyteNeuronsOceansOrganOutcomePathway interactionsPb elementPericapillary CellPericytesPeripheralPerivascular CellPhysiologicPhysiologic AvailabilityPhysiologicalPhysiologyPlasticsPoliciesPollutionPrevalenceProductionPropertyProteinsPublic HealthRaman SpectroscopyRaman Spectrum AnalysisRaman imagingRaman spectrometryRecyclingResearchRiskRisk AssessmentRodent ModelRouget CellsSamplingSiteSprague-Dawley RatsSystemTechniquesTestingTissue SampleTissuesToxic effectToxicitiesToxicologyTravelVisualizationabsorptionastrocytic gliabiologicblood-brain barrier crossingbloodbrain barrierbloodbrain barrier crossingbrain tissuedetection methoddetection proceduredetection techniquedevelopmentalheavy metal Pbheavy metal leadhigh definitionhigh-resolutionimagingimaging mass spectrometryimaging spectroscopyin vivoinhibitorinsightknock-downknockdownmass spectrometric imagingnanonano plasticsneural inflammationneuroinflammationneuroinflammatoryneuron toxicityneuronalneuronal toxicityneurotoxicneurotoxicityneurotoxicologynovelparticlepathwaypollutantrespiratoryresponsesegregationspectroscopic imagingspheroidstranscriptomicstranscytosisuptakewasting
Description preview
Project Summary/Abstract
Plastic pollution is a critical environmental and health issue, with global plastic production reaching 390.7
million metric tons in 2021 and climbing. Only a small fraction of plastic waste is recycled, leading to the
accumulation of plastics in the environment and the unavoidable generation of microplastics and…
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