grant
Polarized Exocytosis: Rabs, Tethers, and SNAREs
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 1 May 1998Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AdipocytesAdipose CellAdult-Onset Diabetes MellitusAllelesAllelomorphsAssayAvidityBindingBioassayBiochemicalBiologicalBiological AssayC-terminalCancersCell BodyCell PolarityCell membraneCell surfaceCellsCollaborationsComplexComputing MethodologiesCryo-electron MicroscopyCryoelectron MicroscopyCytoplasmic MembraneDefectDevelopmentDiseaseDisorderElectron CryomicroscopyExocytosisFamily memberFat CellsGTPGTP PhosphohydrolasesGTPasesGeneHomologGeneralized GrowthGeneticGenetics-MutagenesisGoalsGrowthGuanosine TriphosphateGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesHeadHomologHomologous GeneHomologueHumanHumulin RIn VitroInositide PhospholipidsInositol PhosphoglyceridesInositol PhospholipidsInsulinInvestigationKetosis-Resistant Diabetes MellitusLabelLaboratoriesLipidsLipocytesMalignant NeoplasmsMalignant TumorMature LipocyteMature fat cellMaturity-Onset Diabetes MellitusMediatingMembraneMiceMice MammalsModelingModern ManMolecularMolecular InteractionMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMurineMusMutagenesisMutagenesis Molecular BiologyNIDDMNSF attachment protein receptorNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RPathway interactionsPhosphatasesPhosphatidyl InositolPhosphatidylinositolsPhosphohydrolasesPhosphoinositidesPhosphomonoesterasesPhosphoric Monoester HydrolasesPlasma MembranePlayPoint MutationProcessPropertyProteinsPtdInsRegular InsulinRegulationRegulatory PathwayRoleSNAP receptorSNARESamplingSiteSlow-Onset Diabetes MellitusStable Diabetes MellitusStructureSystemT2 DMT2DT2DMTestingTissue GrowthType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesVesicleWorkYeastsadult onset diabetesbiologiccellular polaritycombatcomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methodcryo-EMcryoEMcryogenic electron microscopydesigndesigningdevelopmentaldimergain of functionguanosinetriphosphatasehuman diseasein vitro activityin vivoinsightinterestketosis resistant diabetesmalignancymaturity onset diabetesmembrane structuremodel buildingmolecular modelingmutantneoplasm/cancernew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapyontogenyparticlepathwayplasmalemmaprotein protein interactionrab G-Proteinsrab GTP-Binding Proteinsrab GTPasesreconstitutereconstitutionresponserhosocial rolesoluble N-ethylmaleimide-sensitive-factor attachment protein receptorspatial and temporalspatial temporalspatiotemporaltraffickingtumortype 2 DMtype II DMtype two diabetesv-SNAREsvesicular SNARE proteinsvesicule SNARE proteins
Description preview
Project Title: Polarized Exocytosis: Rabs, Tethers and SNAREs
Abstract:
The overall goal of this proposal is to understand how regulation and coordination of exocytosis
and cell polarity is achieved within the cell. Our laboratory has played a central role in
determining how Rho/Cdc42 GTPases, the exocyst, and Sro7/Tomosyn family members act in…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click