grant
Point-of-Care Metagenomics for Rapid Detection of pathogens and Antimicrobial Resistance in Sight-Threatening Ocular Infections
Organization MASSACHUSETTS EYE AND EAR INFIRMARYLocation BOSTON, UNITED STATESPosted 1 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20253rd generation sequencingAcanthamoebaAdoptedAntibiotic ResistanceAntimicrobial ResistanceAssayBacteriaBacteria resistanceBacteria resistantBacterial Eye InfectionsBacterial GenomeBacterial Ocular InfectionsBacterial resistantBioassayBioinformaticsBiological AssayBlindnessCausalityCharacteristicsClinicalClinical EvaluationClinical ManagementClinical TestingClinical assessmentsConsumptionCorneaCorneal infectionDNA seqDNA sequencingDNAseqDataData BasesData SetDatabasesDetectionDevelopmentDiagnosisDiagnosticDiagnostic testsDiseaseDisorderDrugsEducational MainstreamingEndophthalmitisEtiologyEyeEye InfectionsEyeballFunctional MetagenomicsGenerationsGenomeGoalsHealthHourInfectionInterventionJudgmentKeratitisLaboratory DiagnosisLeadLiteratureMainstreamingMedicationMetagenomicsMethodsMicrobial keratitisModelingMorbidityMorbidity - disease rateNeedlesOcular InfectionsOcular infections caused by bacteriaOperative ProceduresOperative Surgical ProceduresOphthalmiaOphthalmologyOrganismPathogen detectionPatient CarePatient Care DeliveryPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPb elementPerformancePharmaceutical PreparationsPreparationReportingResearchResearch ResourcesResearch SpecimenResistanceResistance to antibioticsResistant to antibioticsResolutionResourcesSamplingSelection for TreatmentsShotgunsSightSiteSpecimenSurgicalSurgical InterventionsSurgical ProcedureTechnologyTestingThird Generation SequencingTimeToxic effectToxicitiesTreatment FailureUpdateVisionWorkaccurate diagnosisachievement Mainstream Educationanti-microbialanti-microbial agentanti-microbial druganti-microbial resistance emergenceanti-microbial resistantantibiotic drug resistanceantibiotic resistantantimicrobialantimicrobial resistance emergencebacterial resistancebio-informatics toolbiobankbioinformatics toolbiorepositorycare for patientscare of patientscaring for patientscausationclinical applicabilityclinical applicationclinical predictorsclinical testclinical validationcornealdata basedepositorydevelopmentaldiagnostic approachdiagnostic strategydiagnostic tooldisease causationdrug/agenteffective therapyeffective treatmentemerging anti-microbial resistanceemerging antimicrobial resistancefungusgenome repositorygenomic repositoryheavy metal Pbheavy metal leadimprovedin silicoinfections in the corneainfectious keratitisinnovateinnovationinnovativeliving systemmetagenomemetagenome sequencingmetagenomic sequencingmicrobialmicrobial genomicsnano porenanoporenanopore based sequencingnanopore long read seqnanopore long-read sequencingnanopore seqnanopore sequencingnanopore-based long-read sequencingnew technologynovelnovel technologiespandemicpandemic diseasepathogenpathogen genomepathogenomepatient oriented outcomespersonalized diagnosispersonalized diagnosticspoint of carepoint-of-care diagnosticsportabilityprecise diagnosticsprecision diagnosticspreparationsprospectiverapid detectionrepositoryresearch clinical testingresistance mechanismresistance to Bacteriaresistance to Bacterialresistance to anti-microbialresistantresistant mechanismresistant to Bacteriaresistant to Bacterialresistant to antimicrobialresolutionsselection of treatmentshot gunsurgerytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapy failuretherapy selectiontreatment selectionvision lossvisual functionvisual loss
Description preview
PROJECT SUMMARY
Timely and accurate diagnosis of ocular infections is critical to guide early effective therapy and save vision.
However, because current methods for diagnosis of ocular infections are time-consuming and not sensitive,
empirical treatment with broad-spectrum therapies selected on the basis of clinical judgment continues to be the…
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