grant
Point of care detection of fluroquinolone, bedaquiline and linezolid resistant Mycobacterium tuberculosis for rapid treatment decisions.
Organization RUTGERS BIOMEDICAL AND HEALTH SCIENCESLocation Newark, UNITED STATESPosted 26 Feb 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2025AddressAntitubercular DrugsAssayBenemycinBioassayBiological AssayCerebrospinal FluidClinicalCollaborationsCompanionsDNA mutationDetectionDevicesDiagnosticDiagnostic testsDiseaseDisorderDrug resistanceDrug resistance in MtbDrug resistance in Mycobacterium TuberculosisDrug resistant M TuberculosisDrug resistant MtbDrug resistant Mycobacteria TuberculosisDrugsFecesFluoroquinolonesFoundationsFundingFutureGenesGenetic ChangeGenetic defectGenetic mutationGrantIsonicotinic Acid HydrazideLMICLaboratoriesLengthLinezolidM . tuberculosis resistanceM tbM tuberculosisM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMedicationMolecularMtb drug resistanceMtb resistanceMutationMutation DetectionMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMycobacterium tuberculosis resistanceNational Institutes of HealthNucleic Acid Amplification TechnicsNucleic Acid Amplification TechniquesPathway interactionsPatientsPerformancePharmaceutical PreparationsPhasePredispositionReactionReagentResearchResearch ResourcesResearch SpecimenResistanceResourcesRifadinRifampicinRifampinRimactaneRiskSamplingScientistSensitivity and SpecificitySpecificitySpecimenSpinal ColumnSpineSputumStomachSusceptibilitySwabSystemTB diagnosticsTB drugsTB infectionTB therapyTB treatmentTemperatureTestingTubeTuberculosisUnited States National Institutes of HealthUrineVertebral columnZyvoxanti-TB drugsanti-tuberculosis drugsaspirateassay developmentbackbonebasebasescausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcerebral spinal fluidclinical validationdesigndesigningdetection limitdiagnostic developmentdiagnostic platformdiagnostic systemdisseminated TBdisseminated tuberculosisdrug resistance M Tuberculosisdrug resistance Mycobacteria Tuberculosisdrug resistantdrug resistant M.tbdrug/agentgastricgenome mutationhigh riskinfection due to Mycobacterium tuberculosisinnovateinnovationinnovativeinstrumentinternal controlisoniazidlow and middle-income countriesmanufacturemtbmutantnew diagnosticsnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation diagnosticsnext generation therapeuticsnovel diagnosticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwaypoint of carepoint of care testingpoint-of-care detectionpoint-of-care diagnosticsprogramsrapid diagnosisresistance in M . tuberculosisresistance in Mycobacterium tuberculosisresistance to Drugresistantresistant M . tuberculosisresistant Mtbresistant Mycobacterium tuberculosisresistant to Drugspinal fluidstooltreat M. tuberculosistreat Mtbtreat Mycobacterium tuberculosistreat tbtreat tuberculosistuberculosis diagnosticstuberculosis drugstuberculosis infectiontuberculosis therapytuberculosis treatmenttuberculous spondyloarthropathyvalidation studies
Description preview
ABSTRACT
Rapid and sensitive point of care tests that can detect all forms of drug resistance are urgently needed to
enable appropriate treatment for TB. Molecular drug susceptibility tests (mDSTs) which use nucleic acid
amplification techniques to detect mutations associated with resistance to the primary tuberculosis (TB) drugs
isoniazid (INH),…
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