grant
Platelet function abnormalities underlying bleeding in a connective tissue disorder the Ehlers Danlos syndrome
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 1 Sept 2025Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AMCAAMCHAAddressAgonistAngiohemophiliaAssessment instrumentAssessment toolAwarenessBleedingBlood Platelet DisordersBlood Platelet TransfusionBlood PlateletsBlood VesselsBruiseCell Communication and SignalingCell SignalingCell-Extracellular MatrixCharacteristicsClinicalCold-Insoluble GlobulinsCollagenCollagen ReceptorsConnective TissueConnective Tissue DiseasesConnective Tissue DisorderContusionsCutis ElasticaDNA mutationDefectDevelopmentDiagnosisDiagnostic testsDiathesisDisease susceptibilityDown-RegulationDysfunctionECMEhlers-Danlos DiseaseEhlers-Danlos SyndromeEmergenciesEmergency SituationEnvironmentEvaluationExhibitsExtracellular MatrixFN1Factor VIII DeficiencyFemaleFibronectin 1FibronectinsFunctional disorderGenesGenetic ChangeGenetic defectGenetic mutationGuidelinesHemophiliaHemophilia AHemorrhageHemorrhagic DiathesisHemorrhagic DisordersHemostasisHemostatic functionHereditaryHereditary Blood Coagulation DisordersHereditary Coagulation DisordersHereditary DiseaseHumanHypermenorrheaImpairmentIn VitroInborn Genetic DiseasesInfusionInfusion proceduresInheritedInherited Blood Coagulation DisordersInherited Coagulation DisordersInherited disorderIntegrinsIntegrins Extracellular MatrixInternationalInterventionIntracellular Communication and SignalingJoint HypermobilityJoint LaxityKnowledgeLETS ProteinsLaminsLarge External Transformation-Sensitive ProteinLifeLinkMarrow plateletMenorrhagiaMiceMice MammalsModelingModern ManMurineMusMutationOperative ProceduresOperative Surgical ProceduresOpsonic GlycoproteinOpsonic alpha(2)SB GlycoproteinPatientsPhenotypePhysiologicPhysiologicalPhysiopathologyPilot ProjectsPlatelet Aggregation InductionPlatelet Function TestsPlatelet TransfusionPlateletsPltsPopulationPre-Clinical ModelPreclinical ModelsPredispositionProceduresProtocolProtocols documentationReceptor ProteinReportingResearchRiskRoleSamplingSeveritiesSignal TransductionSignal Transduction SystemsSignalingSkinSocietiesSurfaceSurgicalSurgical InterventionsSurgical ProcedureSusceptibilitySymptomsTestingThrombocytesThrombocytopathyThrombosisTooth ExtractionTranexamic AcidType V IF ProteinVascular HemophiliaVon willebrand factor deficiencyWillebrand diseasealpha 2-Surface Binding Glycoproteinbiological signal transductionblood losschronic painclinical applicabilityclinical applicationcohortcutis hyperelasticadevelopmentaldiagnostic approachdiagnostic strategyeffective therapyeffective treatmentelastic skinfibrillogenesisgenome mutationhereditary disorderheritable disorderhigh riskimprovedimproved outcomein vivoinborn errorinfusionsinherited diseasesinherited genetic diseaseinherited genetic disorderinsightintra-vital microscopyintravital microscopyliability to diseasemouse modelmurine modelnew approachesnew diagnosticsnext generation diagnosticsnovelnovel approachesnovel diagnosticsnovel strategiesnovel strategypathophysiologypilot studyplatelet diseaseplatelet disorderplatelet functionpreventpreventingreceptorsocial rolesuccesssurgeryt-AMCHAthrombotic diseasethrombotic disordertranslational opportunitiestranslational potentialvascularvascular abnormalityvon Willebrand Disease♀
Description preview
Summary
Ehlers-Danlos syndrome (EDS) is a heterogeneous group of hereditary connective tissue disorders
characterized by disorganized extracellular matrix due to defects in collagen fibrillogenesis. Bleeding is a
common problem in patients with EDS. Recently, we showed that EDS carries a high risk of hemorrhagic
complications, including bleeding…
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