grant
Plasminogen in glomerular disease progression
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 1 Jul 2020Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025Adhesion PlaquesAlbuminuriaAmilorideAssayBindingBioassayBiological AssayBiological MarkersBiopsyCell BodyCell surfaceCell-Matrix Adherens JunctionsCellsClinicalDetectionDevelopmentDiseaseDisease ProgressionDisorderDistalDropsyEC 3.4.21.7ENaCESKDESRDEdemaEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseEnzyme PrecursorsEpithelial CellsFibrinolysinFocal AdhesionsFocal ContactsGlomerular diseaseGlu-PlasminGoalsHumanHydropsImmunoassayIn VitroInjuryKidneyKidney DiseasesKidney Urinary SystemLinear RegressionsLinkLiquid substanceLogistic RegressionsMeasuresMediatorMedicinal ChemistryMethodsModelingModern ManMolecularMolecular InteractionMorphologyNatureNephronsNephropathyOrganoidsOutcomePatientsPharmaceutic ChemistryPharmaceutical ChemistryPlasminPlasminogenProenzymesProfibrinolysinPropertyProtease FProtein FamilyProteinuriaRegenerative capacityRegulatory PathwayRenal DiseaseRenal Glomerular Diseases and SyndromesRenal functionRenal glomerular diseaseRenal glomerular disease or syndromeRenal glomerular disorderRenal glomerular syndromeResearchRiskRoleSerine EndopeptidasesSerine ProteaseSerine Protein HydrolasesSerine ProteinasesSurvival AnalysesSurvival AnalysisTestingTherapeuticU-PAU-Plasminogen ActivatorUrinary Plasminogen ActivatorUriniferous TubeUrokinaseUrokinase Plasminogen ActivatorUrokinase-Type Plasminogen ActivatorVisceral Epithelial CellWorkZymogensabsorptionbio-markersbiologic markerbiomarkerclinical relevanceclinically relevantcohortdecline in functiondecline in functional statusdevelopmentalefficacy testingepithelial Na+ channelepithelial sodium channelfluidfunctional declinefunctional status declineglomerular filtrationglomerular visceral epithelial cellin vivoinhibitorinjuriesinjury responsekidney disorderkidney functionliquidnebulettenebulinnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpodocyteprogression riskrational designregeneration abilityregeneration capacityrenalrenal disorderresponse to injurysocial roletherapeutic targeturinary
Description preview
Project Summary
Despite significant evidence identifying the podocyte as the key glomerular cell target for injury, validated
therapeutic targets are scarce and commercially available cell-specific therapy is lacking. Additionally, given the
heterogeneous nature of proteinuric kidney disease, biomarkers to identify patients at high versus low risk…
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