grant

Planar cell polarity mechanisms and systems architecture

Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 16 Sept 2019Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanBehaviorBiochemicalBiochemistryBiologic ModelsBiologicalBiological ChemistryBiological ModelsBody TissuesCell BodyCell Communication and SignalingCell ComponentsCell LocomotionCell MigrationCell MovementCell SignalingCell StructureCell divisionCellsCellular MigrationCellular MotilityCellular StructuresComplexCoupledDefectDevelopmentDissectionDrosophilaDrosophila genusEpitheliumEyeEyeballFeedbackFliesGeneticGoalsHairIntracellular Communication and SignalingKnowledgeLogicMath ModelsMedicalModel SystemMolecularOrganism-Level ProcessOrganismal ProcessPathologyPhysiologic ProcessesPhysiological ProcessesProcessProteinsRoleSideSignal TransductionSignal Transduction SystemsSignalingSystemTechnologyTherapeutic InterventionTissuesVertebrate AnimalsVertebratesWorkadulthoodbiologicbiological signal transductioncell motilitydevelopmentalflyfruit flygenetic approachgenetic strategyinnovateinnovationinnovativeinterestintervention therapymathematic modelmathematical modelmathematical modelingmolecular asymmetrymolecular imagingmolecular scalemolecule imagingnovelplanar cell polaritypolarized cellresponsesegregationsingle moleculesocial rolesystem architecturetoolvertebrata
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Description preview

Planar cell polarity (PCP) signaling controls the polarization of cells within the plane of an epithelium, orienting
asymmetric cellular structures, cell divisions and cell migration. Numerous medically important developmental
defects and physiological processes in vertebrates are under control of PCP signaling, motivating considerable
interest in…

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Planar cell polarity mechanisms and systems architecture — STANFORD UNIVERSITY | UNITED STATES | Sept 2019 | Dev Procure