grant
Placental Serotonin: A Potential Mediator of Dieldrin-Related Neurotoxicity and the Developmental Origins of Parkinson’s Disease Risk
Organization RUTGERS BIOMEDICAL AND HEALTH SCIENCESLocation Newark, UNITED STATESPosted 19 Feb 2026Deadline 18 Feb 2028
NIHUS FederalResearch GrantFY202621+ years old5-HT5-Hydroxytryptamine5HTAdultAdult HumanAffectAge MonthsAgingAnimal ModelAnimal Models and Related StudiesApplications GrantsBehaviorBehavioralBirthBody BurdenBody TissuesBrainBrain Nervous SystemCausalityCells Placenta-TissueChemicalsDA NeuronDNA ModificationDNA Modification ProcessDNA mutationDataDegenerative Neurologic DisordersDeveloping fetusDevelopmentDiathesisDieldrinDiseaseDisease susceptibilityDisorderDopamine neuronDoseEmbryoEmbryonicEncephalonEnteramineEnvironmentEnvironmental ExposureEnvironmental FactorEnvironmental Risk FactorEnvironmental ToxinEpidemiologyEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEtiologyExposure toFetal DevelopmentFundingFutureGeneticGenetic ChangeGenetic defectGenetic mutationGrantGrant ProposalsHealthHereditaryHippophaineHumanImpairmentInheritedIntermediary MetabolismKnowledgeLeadLifeLinkMediatingMediatorMetabolic ProcessesMetabolismMiceMice MammalsModelingModern ManModificationMurineMusMutationNAC precursorNIEHSNational Institute of Environmental Health SciencesNeonatalNerve CellsNerve UnitNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural CellNeural Degenerative DiseasesNeural DevelopmentNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurodevelopmental DisorderNeurologicNeurologic Degenerative ConditionsNeurologic DisordersNeurologicalNeurological Development DisorderNeurological DisordersNeuronal DifferentiationNeuronsNormal PlacentomaOutcomePARK1 proteinPARK4 proteinParalysis AgitansParkinsonParkinson DiseaseParturitionPathway interactionsPb elementPhasePlacentaPlacenta Embryonic TissuePlacentomePredispositionPreventionPrimary ParkinsonismProteinsRegulationReportingResearchRiskRisk FactorsSNCASNCA proteinSerotoninSourceStudy modelsSusceptibilitySynaptic plasticitySystemTestingTissuesToxic Environmental AgentsToxic Environmental SubstancesToxic effectToxicitiesWorka-syna-synucleinadulthoodalpha synucleinalpha synuclein genealphaSP22asyncausationchlorinated hydrocarbon pesticidedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldevelopmental neurotoxicitydisease causationdisease riskdisorder riskdopaminergic neuronenvironmental riskenvironmental toxicantepidemiologicepidemiologicalepidemiology research studyepidemiology studyepidemiology surveyepigenetic regulationepigeneticallyexperimentexperimental researchexperimental studyexperimentsexposomeexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesfetalfocus on malefocused on mengene manipulationgenetic manipulationgenetically manipulategenetically perturbgenome mutationheavy metal Pbheavy metal leadlate in lifelate lifeliability to diseaselife spanlifespanmale focusedmale specificmale targetedmodel of animalmonoaminemouse modelmurine modelneonatal brainneuralneurodegenerative illnessneurodevelopmentneurodevelopment effectneurodevelopmental diseaseneurodevelopmental effectneurological diseaseneuron toxicityneuronalneuronal toxicityneurotoxicneurotoxicitynon A-beta component of AD amyloidnon A4 component of amyloid precursornovelorganochlorine pesticidepathwayperinatal developmentpesticide exposurepharmacologicpostnatalpre-formed fibrilprenatalpupsexsporadic Parkinson's Diseasesynapse formationsynaptogenesissynucleinopathytargeted to mentoxicantunbornα synuclein geneα-synα-synuclein
Description preview
Project Summary
The majority of Parkinson’s disease (PD) cases are not caused by an inherited monogenic mutation, and
disease etiology involves a combination of genetic and environmental factors. Epidemiological studies show
that pesticide exposure, particularly to organochlorine pesticides such as dieldrin, increases the risk of
sporadic PD. In a…
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