grant
Pilot Research Project: Evaluating Breast Cancer Patient Populations for Therapeutic Targeting of Aberrant p53, MDM2, MDMX, and PARP signaling
NIHUS FederalResearch GrantFY2025AddressAmericanAnimalsAntioncogene Protein p53BRCA1BRCA1 Gene ProductBRCA1 ProteinBRCA1 geneBiological MarkersBiological Specimen BanksBiological Substance BanksBreast CancerBreast Cancer 1 GeneBreast Cancer 1 Gene ProductBreast Cancer PatientBreast Cancer Type 1 Susceptibility GeneBreast Cancer Type 1 Susceptibility ProteinBreast Tumor PatientBreast-Ovarian Cancer ProteinCancersCell Communication and SignalingCell Culture TechniquesCell LineCell SignalingCellLineCellular Tumor Antigen P53ChromosomesClinicalCollaborationsCommunitiesCommunity OutreachDiagnosisEarly Onset Gene Breast Cancer 1Early Onset Protein Breast Cancer 1Educational workshopEquilibriumEuropeanExposure toFox Chase Cancer CenterGene AmplificationGoalsHDM2HealthHealth FairsHereditary Breast Cancer 1HeterograftHeterologous TransplantationImaging technologyImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIncidenceIndividualInformed ConsentIntracellular Communication and SignalingLearningMDM2MDM2 geneMDMX proteinMalignant Breast NeoplasmMalignant NeoplasmsMalignant TumorMdm-2 proteinMentorshipMicroarray AnalysisMicroarray-Based AnalysisNeoplasm Circulating CellsOncoprotein MDM2Oncoprotein p53OutcomeP53PARP InhibitorPARP-1 inhibitorPARPiPDX modelPathologyPatient derived xenograftPatientsPhosphoprotein P53Phosphoprotein pp53Pilot ProjectsPoly(ADP-ribose) Polymerase InhibitorPoly(ADP-ribose) polymerase 1 inhibitorProbabilityProliferatingProtein TP53ProteinsR-Series Research ProjectsR01 MechanismR01 ProgramRNF53ResearchResearch GrantsResearch Project GrantsResearch ProjectsResearch SpecimenRoleSamplingScientistSignal TransductionSignal Transduction SystemsSignalingSingle Base PolymorphismSingle Nucleotide PolymorphismSpecimenStaining methodStainsStrains Cell LinesStudentsTNBCTP53TP53 geneTRP53TestingTissue ArraysTissue ChipTissue MicroarrayTrainingTumor Protein p53Tumor Protein p53 GeneUniversitiesWorkWorkshopXenograftXenograft procedureXenotransplantationaggressive breast canceranimal imagingbalancebalance functionbio-markersbiologic markerbiological researchbiological signal transductionbiological specimen repositorybiomarkerbiosample repositorybiospecimen bankbiospecimen repositorybrca 1 genecancer biomarkerscancer markerscell culturecell culturescirculating neoplastic cellcirculating tumor cellcollegecollegiatecultured cell lineempowermentexperienceimprovedindividuals with breast cancerinhibitor druginhibitor therapeuticinhibitor therapymalignancymalignant breast tumormdm-2 oncogene proteinmdm2 proteinmicroarray analysesmicroarray technologymouse modelmurine modelmutantnatural gene amplificationneoplasm/cancernext generationnovelp53 Antigenp53 Genesp53 Tumor Suppressorp53-Binding Protein MDM2patient derived xenograft modelpatient populationpatients with breast cancerperson with breast cancerpilot studyprotein biomarkersprotein markersprotein p53replication stressscreeningscreeningssingle nucleotide variantsocial rolespecimen bankspecimen repositorystudent mentoringstudent-led learningtherapeutic targettriple-negative breast cancertriple-negative invasive breast carcinomatumorxeno-transplantxeno-transplantation
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Project Summary
Partnerships are needed to overcome challenges that have limited systematic biological research on the underpinnings of communities with a higher incidence of aggressive triple negative breast cancer (TNBC). Our U54 partnership augments the ability to study uncommonly studied protein biomarkers in order to improve screening and…
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