grant
Pilot Project 5 - Pancreatic Treatment
Organization FLORIDA AGRICULTURAL AND MECHANICAL UNIVLocation TALLAHASSEE, UNITED STATESPosted 19 Sept 2018Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20251-OHP2'-Deoxycytidine Kinase5-FU5-Fluracil5FUARA-C KinaseAddressCaliforniaCamptoCancer BurdenCancer CauseCancer EtiologyCancersCaringCatchment AreaCessation of lifeCytidine AminohydrolaseCytidine DeaminaseDCK geneData SetDeathDeoxycytidine KinaseDeoxycytidine Kinase GeneDiagnosisDifluorodeoxycytidineDrug KineticsDrug usageEC 2.7.1.74EGF ReceptorEGFRERBB ProteinEducationEducational aspectsEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor KinaseEpidermal Growth Factor Receptor Protein-Tyrosine KinaseEpidermal Growth Factor-Urogastrone ReceptorsEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExposure toFc ReceptorFloridaFluoro UracilFluorouracilFluoruracilFluouracilFolinic AcidFolinic Acid-SFFormulationGene ExpressionGeneticGoalsHER1HealthHigh PrevalenceHumanIncidenceIndividualIntermediary MetabolismInvestigationKnowledgeL-LeucovorinLeucovorinLeukovorumLevofolinic acidLevoleucovorinLinkMalignant NeoplasmsMalignant TumorMeasuresMetabolic ProcessesMetabolismMiceMice MammalsModelingModern ManMurineMusNational Cancer BurdenNon-Polyadenylated RNANucleoside Transport ProteinsNucleoside TransporterOperative ProceduresOperative Surgical ProceduresOrganoidsOutcomePDAC cancer cellPDAC cellPDX modelPancreasPancreas Ductal AdenocarcinomaPancreas NeoplasmsPancreas TumorPancreaticPancreatic Ductal AdenocarcinomaPancreatic TumorPatient derived xenograftPatientsPharmacokineticsPhosphorylationPilot ProjectsPopulationProtein PhosphorylationProteinsPublishingRNARNA Gene ProductsResistanceRibonucleic AcidRiskSNP genotypingSYS-TXSafetySamplingSolubilitySurfaceSurgicalSurgical InterventionsSurgical ProcedureSurvival RateSystemic TherapyTGF-alpha ReceptorTestingToxic effectToxicitiesTransforming Growth Factor alpha ReceptorTreatment EfficacyUrogastrone ReceptorVariantVariationWild Type Mouseanti-cancer researchantibody receptoranticancer activityc-erbB-1c-erbB-1 Proteincamptosarcancer researchchemotherapycitrovorumcohortdFdCdFdCyddesigndesigningdetermine efficacydrug useefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationefficacy testingenzyme activityepigeneticallyerbB-1erbB-1 Proto-Oncogene ProteinerbBlevaluate efficacyexamine efficacyexperienceexperimentexperimental researchexperimental studyexperimentsgemcitabinehigh riskimprovedin vivointervention efficacyirinotecanlipophilicitymalignancymortalitymouse modelmurine modelnano particlenano-sized particlenanoparticlenanosized particleneoplasm/canceroxaliplatinoxaliplatinepancreatic ductal adenocarcinoma cellpancreatic neoplasiapancreatic neoplasmpatient derived xenograft modelpatient stratificationpersonalized chemotherapypilot studyprecision chemotherapyprotein expressionproto-oncogene protein c-erbB-1resistantresponsesingle nucleotide polymorphism genotypingsite targeted deliverystratified patientsubcutaneoussubdermalsurgerytargeted deliverytherapeutic efficacytherapeutic outcometherapy efficacytherapy outcometreatment choicetumortumor growthtumor xenograftuptakewildtype mouse
Description preview
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human malignancies and the survival rate remains stagnant with a 5-year survival rate of only 5-8%. Some populations in our catchment area have higher risk for PDAC and lower survival following treatment. FOLFIRINOX (5-fluorouracil, leucovorin, oxaliplatin, and irinotecan) is…
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